Relapsing-remitting multiple sclerosis diagnosis from cerebrospinal fluids via fourier transform infrared spectroscopy coupled with multivariate analysis

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dc.contributor.authorYonar, Dilek
dc.contributor.authorOcek, Levent
dc.contributor.authorTiftikçioğlu, Bedile İrem
dc.contributor.authorZorlu, Yaşar
dc.contributor.authorSevercan, Feride
dc.date.accessioned2021-05-15T12:41:58Z
dc.date.available2021-05-15T12:41:58Z
dc.date.issued2018
dc.departmentTıp Fakültesi, Biyofizik Anabilim Dalıen_US
dc.descriptionTiftikcioglu, B. Irem/0000-0002-4573-3844; Yonar, Dilek/0000-0001-6480-855X
dc.description.abstractMultiple sclerosis (MS) is a chronic, progressive, inflammatory and degenerative disease of central nervous system. Here, we aimed to develop a method for differential diagnosis of Relapsing-Remitting MS (RRMS) and clinically isolated syndrome (CIS) patients, as well as to identify CIS patients who will progress to RRMS, from cerebrospinal fluid (CSF) by infrared (IR) spectroscopy and multivariate analysis. Spectral analyses demonstrated significant differences in the molecular contents, especially in the lipids and Z conformation of DNA of CSF from CIS, CIS to RRMS transformed (TCIS) and RRMS groups. These changes enables the discrimination of diseased groups and controls (individuals with no neurological disease) from each other using hierarchical cluster and principal component analysis. Some CIS samples were consistently clustered in RRMS class, which may indicate that these CIS patients potentially will transform to RRMS over time. Z-DNA band at 795 cm(-1) that is existent only in diseased groups and significant increase in carbonyl amount, decrease in amideI/amide II and lipid/protein ratios observed only for RRMS groups can be used as diagnostic biomarkers. The results of the present study shed light on the early diagnosis of RRMS by IR spectroscopy complemented with multivariate analysis tools.en_US
dc.identifier.doi10.1038/s41598-018-19303-3
dc.identifier.issn2045-2322
dc.identifier.pmid29348591
dc.identifier.scopus2-s2.0-85040840465
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1038/s41598-018-19303-3
dc.identifier.urihttps://hdl.handle.net/20.500.12939/878
dc.identifier.volume8en_US
dc.identifier.wosWOS:000422736400006
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSevercan, Feride
dc.language.isoen
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofScientific Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMedicineen_US
dc.subjectSclerosis Diagnosisen_US
dc.subjectATR-FTIRen_US
dc.titleRelapsing-remitting multiple sclerosis diagnosis from cerebrospinal fluids via fourier transform infrared spectroscopy coupled with multivariate analysis
dc.typeArticle

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