Tandem high-dose chemotherapy followed by autologous stem cell transplantation: An infant with trilateral retinoblastoma

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dc.contributor.authorTöret, Ersin
dc.contributor.authorÖzdemir, Zeynep Canan
dc.contributor.authorZengin Ersoy, Gizem
dc.contributor.authorÖztunalı, Çiğdem
dc.contributor.authorBozkurt, Ceyhun
dc.contributor.authorKebudi, Rejin
dc.date.accessioned2023-03-20T06:37:30Z
dc.date.available2023-03-20T06:37:30Z
dc.date.issued2023en_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractBackground: Retinoblastoma (RB) is the most common intraocular malignancy in childhood. Advanced RB, associated with exceedingly poor prognosis, requires more intensive multiagent chemotherapy than conventional regimens. Rescue of the bone marrow after intensive chemotherapy is achieved with stem cell transplantation. The sequential courses (tandem transplantation) of high-dose chemotherapy followed by autologous stem cell transplantation allow for even greater dose intensity in consolidation with the potential to use different active chemotherapeutics at each transplant and have proven feasible and successful in treating children with recurrent/refractory solid tumors. Case description: We report an infant with trilateral high-risk RB who received tandem high-dose chemotherapy (HDC) followed by autologous stem cell transplantation after the conventional chemotherapy. A 5-month-old female patient presented with strabismus, and the ophthalmoscopic examination showed intraocular tumoral lesions in both eyes. Magnetic resonance imaging (MRI) concluded the trilateral retinoblastoma diagnosis due to a tumoral mass in the optic chiasm. The follow-up ophthalmologic examinations and the MRI detected stable disease after six cycles of multiagent chemotherapy. Conclusions: Rescue with autologous stem cell transplantation after HDC allows for an increase in chemotherapy intensity. Tandem transplantation provides the chance to perform different chemotherapeutics at each transplant and enables an increase in the chemotherapy intensity, thus providing a positive effect on disease-free survival.en_US
dc.identifier.citationTöret, E., Özdemir, Z. C., Zengin Ersoy, G., Öztunalı, C., Bozkurt, C., & Kebudi, R. (2023). Tandem high‐dose chemotherapy followed by autologous stem cell transplantation: An infant with trilateral retinoblastoma. Pediatric Transplantation.en_US
dc.identifier.issn1397-3142
dc.identifier.issn1399-3046
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85150687399
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/20.500.12939/3447
dc.identifier.volume27en_US
dc.identifier.wosWOS:000950364500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorZengin Ersoy, Gizem
dc.language.isoen
dc.relation.ispartofPediatric transplantation
dc.relation.isversionof10.1111/petr.14504en_US
dc.relation.publicationcategoryRaporen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutologous stem cellsen_US
dc.subjectPediatricen_US
dc.subjectSolid tumorsen_US
dc.subjectTandem transplantationen_US
dc.subjectTrilateral retinoblastomaen_US
dc.titleTandem high-dose chemotherapy followed by autologous stem cell transplantation: An infant with trilateral retinoblastoma
dc.typeReport

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