Evaluation of the risk factors for BK virus-associated hemorrhagic cystitis in pediatric bone marrow transplantation patients: Does post-transplantation cyclophosphamide increase the frequency?

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dc.authorid0000-0002-8968-9849en_US
dc.authorid0000-0001-8338-2101en_US
dc.contributor.authorErsoy, Gizem Zengin
dc.contributor.authorBozkurt, Ceyhun
dc.contributor.authorAksoy, Başak Adaklı
dc.contributor.authorÖner, Özlem Başoğlu
dc.contributor.authorAydoğdu, Selime
dc.contributor.authorÇipe, Funda
dc.contributor.authorSütçü, Murat
dc.contributor.authorÖzkaya, Ozan
dc.contributor.authorFışgın, Tunç
dc.date.accessioned2022-07-25T08:34:10Z
dc.date.available2022-07-25T08:34:10Z
dc.date.issued2022en_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractBackground: BKV-HC is one of the most significant complications of HSCT. This ret -rospective study aimed to determine the frequency of BKV-HC in pediatric patients undergoing HSCT, detect the associated risk factors for the development of BKV-HC, and explore the effects of post-transplantation Cy use.Methods: Three hundred twenty-seven patients (girls: 121, boys: 206) were analyzed according to sex, conditioning regimen, transplantation type, donor relatedness, stem cell source, the presence and grade of aGVHD, CMV co-existence, and Cy use.Results: Multivariate analysis confirmed the prognostic importance of age (OR: 4.865), TBI use, the presence of aGVHD (OR: 2.794), CMV coinfection (OR: 2.261), and Cy use (OR: 27.353). A statistically significant difference was found between the mean BKV-HC follow-up times compared with post-transplantation Cy intake (p< .001). The BKV-HC rate increased as the number of risk factors of the patient increased.Conclusion: BKV-HC is an essential complication of HSCT primarily associated with Cy use, the presence of aGVHD, and donor relatedness. The present study shows that the use of Cy in the post-transplantation period further increases BKV-HC risk in pediatric patients, regardless of dose.en_US
dc.identifier.citationErsoy, G. Z., Bozkurt, C., Aksoy, B. A., Öner, Ö. B., Aydoğdu, S., Çipe, F.,Sütçü, M., Özkaya, O., & Fışgın, T. (2022). Evaluation of the risk factors for BK virus‐associated hemorrhagic cystitis in pediatric bone marrow transplantation patients: Does post‐transplantation cyclophosphamide increase the frequency?. Pediatric Transplantation.en_US
dc.identifier.scopus2-s2.0-85134192838
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2715
dc.identifier.wosWOS:000826868600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErsoy, Gizem Zengin
dc.institutionauthorAksoy, Başak Adaklı
dc.institutionauthorÖner, Özlem Başoğlu
dc.institutionauthorÇipe, Funda
dc.institutionauthorFışgın, Tunç
dc.language.isoen
dc.relation.ispartofPediatric Transplantation
dc.relation.isversionof10.1111/petr.14364en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBK Virus Hemorrhagic Cystitisen_US
dc.subjectPost Transplantation Cyclophosphamideen_US
dc.subjectStem Cell Transplantationen_US
dc.titleEvaluation of the risk factors for BK virus-associated hemorrhagic cystitis in pediatric bone marrow transplantation patients: Does post-transplantation cyclophosphamide increase the frequency?
dc.typeArticle

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