Advances in vaccine adjuvant development and future perspectives
Yükleniyor...
Dosyalar
Tarih
2025
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor and Francis Ltd.
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Use of highly purified antigens to improve vaccine safety has led to reduced immunogenicity and efficacy, resulting in the need for adjuvants to increase and/or modulate the immunogenicity of the vaccine. Despite the need for potent and safe vaccine adjuvants, currently, there are still very few adjuvants in licensed human vaccines. Advances in immunology and molecular biology, especially in the last decade, have allowed researchers to understand better how the adjuvants work and enhance immune responses. While aluminum salts are still the most widely used adjuvants, research has shifted toward the rational design of adjuvant systems containing immunostimulatory molecules. Application of systems biology, which is based on high-throughput technologies using mathematical and computational modeling, has provided a deeper understanding of the biological events elicited by vaccination as well as the influence of other factors such as sex, age, microbiota, genetics and metabolism on the immune response. By this means, it became possible to tailor potential vaccine adjuvants more precisely for a successful vaccine with enhanced efficacy, safety and protection. In this review, after describing the mechanism of action of the adjuvants, current adjuvants in licensed vaccines, as well as those under clinical development will be mentioned in detail. Finally, new approaches in vaccine adjuvant development using systems biology and artificial intelligence will be reviewed, and future directions in vaccine research in regard to efficacy, safety and quality aspects will be discussed.
Açıklama
Article number : 2517137
CODEN : DDELE
Anahtar Kelimeler
Clinical trials, licensed vaccine adjuvants, mechanism of action, metabolic and epigenetic adjuvants, microbiota, systems biology, tissue-resident memory responses
Kaynak
Drug Delivery
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
32
Sayı
1
Künye
Sinani, G., & Şenel, S. (2025). Advances in vaccine adjuvant development and future perspectives. Drug Delivery, 32(1), 2517137. 10.1080/10717544.2025.2517137
