Epidemiologic and microbiologic evaluation of catheter-line bloodstream infection in a pediatric hematopoietic stem cell transplant center

Basit Öğe Kaydı
dc.contributor.authorAdaklı Aksoy, Başak
dc.contributor.authorKara, Manolya
dc.contributor.authorSütçü, Murat
dc.contributor.authorÖzbek, Ahmet
dc.contributor.authorZengin Ersoy, Gizem
dc.contributor.authorBaşoğlu Öner, Özlem
dc.contributor.authorAydoğdu, Selime
dc.contributor.authorGül, Doruk
dc.contributor.authorBozkurt, Ceyhun
dc.contributor.authorFışgın, Tunç
dc.date.accessioned2023-08-22T08:44:36Z
dc.date.available2023-08-22T08:44:36Z
dc.date.issued2023en_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractBackground: Children who underwent hematopoietic stem cell transplant (HSCT) are at high risk of developing central-line-associated bloodstream infection (CLABSIs). The present study aimed to identify possible risk factors for mortality by analyzing the clinical and laboratory characteristics of patients diagnosed with CLABSI in our pediatric HSCT unit. Methods: The initial CLABSI episodes of 102 children were analyzed. Medical records of the patients were evaluated by preformed standardized surveys. Univariate analysis and multivariate logistic regression analysis were performed to identify risk factors for mortality. Results: Thirty-five patients (34.3%) were female. The median age was 48 month (3-204). The median time to onset of CLABSI was 19 days (4-150). The Gram-negative/Gram-positive bacteria ratio among the causative agents was 57.8 % to 34.3 %. The mortality rate was 12.6%. The presence of severe neutropenia, initiation of inappropriate empirical antibiotic therapy, the presence of hypotension, persistent bacteremia, pediatric intensive care unit admission, growth of carbapenemase-positive Gram-negative microorganism and multi-drug resistant bacteria were significantly high in the mortality group when compared to survivors. The presence of hypotension, inappropriate empirical antibiotic therapy, and persistent bacteremia were found to be independent risk factors for mortality. Conclusion: Rational use of antibiotics, active surveillance/ screening of patients together with improved infection control practices may reduce the incidence and the consequences of CLABSIs.en_US
dc.identifier.citationAksoy, B. A., Kara, M., Sütçü, M., Özbek, A., Ersoy, G. Z., Öner, Ö. B., ... & Fışgın, T. (2023). Epidemiologic and microbiologic evaluation of catheter-line bloodstream infection in a pediatric hematopoietic stem cell transplant center. American Journal of Infection Control, 52(1), 81-86.en_US
dc.identifier.endpage86en_US
dc.identifier.issn0196-6553
dc.identifier.issn1527-3296
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85173185534
dc.identifier.scopusqualityQ1
dc.identifier.startpage81en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/3707
dc.identifier.volume52en_US
dc.identifier.wosWOS:001142892900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAdaklı Aksoy, Başak
dc.institutionauthorÖzbek, Ahmet
dc.institutionauthorZengin Ersoy, Gizem
dc.institutionauthorBaşoğlu Öner, Özlem
dc.institutionauthorAydoğdu, Selime
dc.institutionauthorFışgın, Tunç
dc.language.isoen
dc.relation.ispartofAmerican Journal of Infection Control
dc.relation.isversionof10.1016/j.ajic.2023.08.010en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCentral Venous Catheteren_US
dc.subjectCatheter-Line Bloodstream Infectionen_US
dc.subjectHematopoietic Stem Cell Transplantationen_US
dc.subjectPediatric Canceren_US
dc.titleEpidemiologic and microbiologic evaluation of catheter-line bloodstream infection in a pediatric hematopoietic stem cell transplant center
dc.typeArticle

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

PubMed İndeksli Yayınlar Koleksiyonu
Dahili Tıp Bilimleri Bölümü Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu