Nucleosome assembly protein 1-like 1 (NAP1L1) in gastric cancer patients: a potential biomarker with diagnostic and prognostic utility

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dc.contributor.authorGül, Güngör
dc.contributor.authorAydın, Mehmet Akif
dc.contributor.authorAlgül, Şermin
dc.contributor.authorKızıltan, Remzi
dc.contributor.authorKemik, Özgür
dc.date.accessioned2024-02-20T11:59:49Z
dc.date.available2024-02-20T11:59:49Z
dc.date.issued2024en_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü,Genel Cerrahi Ana Bilim Dalıen_US
dc.description.abstractBackground: The nucleosome assembly protein 1-like 1 (NAP1L1) is suggested to have an oncogenic role in several tumors based on its overexpression. However, its diagnostic and prognostic role in gastric cancer remains unclarified. This study aimed to evaluate the diagnostic and prognostic utility of NAP1L1 in gastric cancer patients. Methods: A total of 85 patients [mean (SD) age: 60.9 (1.6) years, 49.4% were males] with newly-diagnosed gastric cancer and 40 healthy individuals [mean (SD) age: 60.7 (1.7) years, 52.5% were males] were included. Data on patient demographics (age, gender), TNM stages and tumor size, and the serum NAP1L1 levels were recorded. Results: Serum NAP1L1 levels were significantly higher in gastric cancer patients than in control subjects [12 (9.5-13.8) vs. 1.8 (1.5-2.4) ng/mL, p < 0.001]. Also, certain tumor characteristics such as tumor size of >4 vs. <4 cm (p < 0.001), M1 vs. M0 stage (p < 0.001), N2 vs. N0 and N1 stage (p < 0.001), and T4 vs. lower T stage (p < 0.001) were associated with significantly higher serum NAP1L1 levels in gastric cancer patients. Conclusions: Our findings revealed for the first time that serum levels for NAP1L1 were overexpressed in the gastric cancer, as also correlated with the disease progression. NAP1L1 seems to be a potential biomarker for gastric cancer, providing clinically important information on early diagnosis and risk stratification.en_US
dc.identifier.citationGul, G., Aydin, M. A., Algul, S., Kiziltan, R., & Kemik, O. (2024). Nucleosome assembly protein 1-like 1 (NAP1L1) in gastric cancer patients: A potential biomarker with diagnostic and prognostic utility. Biomarkers, (just-accepted), 29(1), 30-35. 10.1080/1354750X.2024.2309540en_US
dc.identifier.endpage35en_US
dc.identifier.issn1354-750X
dc.identifier.issn1366-5804
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85184448965
dc.identifier.scopusqualityQ2
dc.identifier.startpage30en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4594
dc.identifier.volume29en_US
dc.identifier.wosWOS:001158224500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAydın, Mehmet Akif
dc.language.isoen
dc.relation.ispartofBiomarkers
dc.relation.isversionof10.1080/1354750X.2024.2309540en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGastric canceren_US
dc.subjectNAP1L1en_US
dc.subjectEarly diagnosisen_US
dc.subjectMarkeren_US
dc.subjectRisk stratificationen_US
dc.titleNucleosome assembly protein 1-like 1 (NAP1L1) in gastric cancer patients: a potential biomarker with diagnostic and prognostic utility
dc.typeArticle

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