Evidence for health-promoting properties of Lepidium Sativum L.: an updated comprehensive review

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dc.contributor.authorHekmatshoar, Yalda
dc.contributor.authorÖzkan, Tülin
dc.contributor.authorSaadat, Yalda Rahbar
dc.date.accessioned2022-12-28T06:52:13Z
dc.date.available2022-12-28T06:52:13Z
dc.date.issued2022en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri, Tıbbi Biyoloji Ana Bilim Dalıen_US
dc.description.abstractLepidium sativum L. is a common herb distributed worldwide, used as a food ingredient and therapeutic agent in traditional medicine for treating health-related disorders. L. sativum and its extracts have been described to possess numerous biological activities including antimicrobial, antidiabetic, antioxidant, antidiarrheal, anticancer, and numerous health-promoting effects in in vivo and in vitro studies. The purpose of this review is to summarize the findings describing important biological functions and therapeutic effects of L. sativum in various cell lines and animal models. In this review, the English-language articles were gathered from electronic databases including Web of Science, PubMed and Google Scholar with no time limit applied to any database. The search terms used in this review include, "Lepidium sativum L." and/or "chemical composition", "health benefits", "antimicrobial", "antioxidant", "anticancer", "diuretic", "nephro-protection", "antidiarrheal", "antidiabetic", "anti-asthmatic", "neuroprotection", "metabolic", "bone fracture", and "reproductive performance". Additional and eligible studies were collected from reference lists of appropriate articles. The information presented will be helpful to attract more interest toward medicinal plants by defining and developing novel clinical applications and new drug formulations in the future. Pre-clinical studies showed that L. sativum possesses potent health-promoting effects involving various molecular mechanisms. Taken all together, data suggested that identified herbal plants such as L. sativum, can be exploited as nutritional and therapeutic agents to combat various ailments. Despite much research in this field, further comprehensive in vitro/in vivo studies and clinical trials are needed to identify the mechanisms underlying the biological and therapeutic activities of L. sativum.en_US
dc.identifier.citationHekmatshoar, Y., Özkan, T.,Saadat, Y. R. (2022). Evidence for health-promoting properties of Lepidium Sativum L.: an updated comprehensive review. Turkish Journal of Pharmaceutical Sciences, 19(6), 714-723.en_US
dc.identifier.endpage723en_US
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85144499783
dc.identifier.scopusqualityQ2
dc.identifier.startpage714en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/3170
dc.identifier.volume19en_US
dc.identifier.wosWOS:000906799100015
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorHekmatshoar, Yalda
dc.language.isoen
dc.relation.ispartofTurkish Journal Of Pharmaceutical Sciences
dc.relation.isversionof10.4274/tjps.galenos.2021.07504en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEthnomedicineen_US
dc.subjectLepidium Sativumen_US
dc.subjectMedicinal Plantsen_US
dc.subjectNutraceuticalen_US
dc.subjectTherapeutic Agentsen_US
dc.titleEvidence for health-promoting properties of Lepidium Sativum L.: an updated comprehensive review
dc.typeArticle

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