Chemotherapy and radiation induced pulmonary dysfunction in hodgkin lymphoma patients

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dc.contributor.authorGüner, Şebnem İzmir
dc.contributor.authorYanmaz, Mustafa Teoman
dc.contributor.authorSelvi, Ahmet
dc.contributor.authorUsul, Çiğdem
dc.date.accessioned2021-05-15T12:36:56Z
dc.date.available2021-05-15T12:36:56Z
dc.date.issued2016
dc.departmentTıp Fakültesien_US
dc.descriptionAfsar, Cigdem Usul/0000-0002-3764-7639; Afsar, Cigdem Usul/0000-0002-3764-7639
dc.description.abstractAlthough the deterioration in pulmonary functions is a well-known important problem due to the treatment of the Hodgkin's lymphoma patients, the immediate and long term effects of the therapy and its distinctive components were not shown clearly yet. We planned to investigate effects of multiple agent chemotherapy and/or radiotherapy to pulmonary functions immediately and thereafter and the possible effects of the managing this situation. 34 patients were included the study. The patients were evaluated for peak expiratory flow (PEF), forced expiratory volume in 1 s (FEV1), forced expiratory vital capacity (FVC), mean total lung capacity (TLC) values, FEV1/FVC ratio, diffusing capacity for carbonmonoxide (DLco), diffusing capacity for carbonmonoxide corrected for hemoglobin concentration (DLCO) before and at 1, 6 and 12 months after the initiation of the treatment. Demographic characteristics; disease stages; chemotherapy protocols; whether radiotherapy is received; if yes, the region and the dose received were recorded. The tests were finally analysed in two separated groups; group A treated with only chemotherapy and group B; treated with combination therapy, chemotherapy and radiotherapy. In group A, FVC and FEV1 is similar before and after treatment. FEV1/FVC ratio was increased (P = 0.0001) in this group despite increasing in mean TLC values (P = 0.001). No meaningful changes were observed in PEF and DLCO values in group A. In group B, FVC, FEV1 and PEF were decreased after treatment (for FVC P = 0.028, for FEV1 P = 0.04). Despite a decrease in first month of the treatment in FEV1/FVC ratio and DLco these two parameters were recovered at the end of the first year in group B patients. TLC values were increased after treatment in group B as in group A (P = 0.035). We believe that, if these patients are managed well in 1 year; necessary precautions are provided; and patients are well-informed, then there wouldn't be too much risk and mortality rate for long-term side effects of ABVD and mediastinal RT.en_US
dc.identifier.doi10.1007/s12288-015-0619-x
dc.identifier.endpage436en_US
dc.identifier.issn0971-4502
dc.identifier.issn0974-0449
dc.identifier.issue4en_US
dc.identifier.pmid27812252
dc.identifier.scopus2-s2.0-84947438483
dc.identifier.scopusqualityQ3
dc.identifier.startpage431en_US
dc.identifier.urihttps://doi.org/10.1007/s12288-015-0619-x
dc.identifier.urihttps://hdl.handle.net/20.500.12939/441
dc.identifier.volume32en_US
dc.identifier.wosWOS:000386685400010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüner, Şebnem İzmir
dc.language.isoen
dc.publisherSpringer Indiaen_US
dc.relation.ispartofIndian Journal of Hematology and Blood Transfusion
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHodgkin lymphomaen_US
dc.subjectPulmonary Dysfunctionen_US
dc.subjectChemotherapyen_US
dc.subjectRadiationen_US
dc.titleChemotherapy and radiation induced pulmonary dysfunction in hodgkin lymphoma patients
dc.typeArticle

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