In vitro physiological effects of Origanum onites L. (Lamiaceae) essential oil treatment on human origin cell lines

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dc.contributor.authorGündoğan, Gül İpek
dc.contributor.authorNath, Ebru Özdemir
dc.date.accessioned2021-05-15T11:33:18Z
dc.date.available2021-05-15T11:33:18Z
dc.date.issued2021
dc.departmentEczacılık Fakültesi, Farmasötik Botanik Anabilim Dalıen_US
dc.description.abstractOriganum onites L. belongs to the Lamiaceae family which is commonly used for symptomatic treatment of the diseases of the gastrointestinal, endocrine, and respiratory systems in Turkish ethnobotanical studies and public. In this study our aim was to investigate the physiological effects of O. onites essential oil (OE) on A549 human lung cancer, MIA PaCa human pancreas cancer and HUVEC human endothelial cell lines. Our findings showed that O. onites OE treatment at all concentrations (4.79-191.6 mu g/mL, 24 h) can inhibit cell proliferation and induce apoptosis in A549 and MIA PaCa cell lines (P < 0.0001). Although <= 19.16 mu g/mL OE treatment for 24 h did not inhibit cell proliferation in the HUVEC cell lines, higher concentrations of OE (>= 38.32 mu g/mL) significantly inhibited cell proliferation. Apoptotic cell counts were significantly (P < 0.0001) higher in all cell lines at both incubation times (24 h 56.3 +/- 7%, 48 h 53 +/- 5% for A549, 24 h 44 +/- 7%, 48 h 44.7 +/- 7% for MIA PaCa, 24 h 48.7 +/- 6%, 48 h 49.3 +/- 5% for HUVEC). Migration rates were decreased significantly (P < 0.0001) (24 h 64 +/- 6%, 48 h 67.2 +/- 4% for A549, 24 h 49 +/- 5%, 48 h 69.35 +/- 5% for MIA PaCa, 24 h 47 +/- 5%, 48 h 69.6 +/- 2% for HUVEC). Based on these results, OE has been shown to have promising anticancer effects.en_US
dc.identifier.doi10.3906/bot-2010-40
dc.identifier.endpage171en_US
dc.identifier.issn1300-008X
dc.identifier.issn1303-6106
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85103675840
dc.identifier.scopusqualityQ2
dc.identifier.startpage158en_US
dc.identifier.trdizinid438597
dc.identifier.urihttps://doi.org/10.3906/bot-2010-40
dc.identifier.urihttps://hdl.handle.net/20.500.12939/125
dc.identifier.volume45en_US
dc.identifier.wosWOS:000635960800005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorNath, Ebru Özdemir
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Botany
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOriganum Onitesen_US
dc.subjectCellular-Migrationen_US
dc.subjectApoptosisen_US
dc.subjectProliferationen_US
dc.subjectCanceren_US
dc.subjectWound Healingen_US
dc.titleIn vitro physiological effects of Origanum onites L. (Lamiaceae) essential oil treatment on human origin cell lines
dc.typeArticle

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