Immune reconstitution in the patients with talasemia major after hematopoietic stem cell transplantation

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dc.contributor.authorErman, Baran
dc.contributor.authorAdaklı Aksoy, Başak
dc.date.accessioned2021-05-15T11:33:57Z
dc.date.available2021-05-15T11:33:57Z
dc.date.issued2020
dc.departmentTıp Fakültesi, Çocuk Sağlığı ve Çocuk Hastalıkları Anabilim Dalıen_US
dc.description.abstractIntroduction: Beta-thalaccemia (beta-TM) is one of the most common, autosomal recessive inherited hematologic disorder in the world. Since hematopoietic stem cell transplantation (HSCT) is the only curative treatment, determination of cellular immune reconstitution is crucial for understanding of a successful clinical outcome. Here, we evaluated lymphoid reconstitution in pediatric patients with thalassemia major after stem cell transplantation. Material and Methods: The study included 20 patients with beta-thalassemia major who underwent HSCT. We assessed the clinical and laboratory information of the patients retrospectively. Results: After one year from transplantation, all patients were alive and blood transfusion independent. CD4(+) T cell recovery was poor and CD4/CD8 ratio was impaired in the vast majority of the patients. Percentages and absolute counts of the other lymphoid cells generally reached the normal levels within 12 months. Seventeen patients had full donor chimerism while only 3 of 20 had low chimerism levels ranging between 55-86%. Conclusion: Although a successful clinical course and immune reconstitution were observed, the patients should be followed up carefully. Because, the poor engraftment of CD4(+) T lymphocytes may lead severe infections in the patients.en_US
dc.identifier.doi10.25002/tji.2020.1238
dc.identifier.endpage119en_US
dc.identifier.issn1301-109X
dc.identifier.issn2147-8325
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85098670833
dc.identifier.scopusqualityQ4
dc.identifier.startpage113en_US
dc.identifier.trdizinid474289
dc.identifier.urihttps://doi.org/10.25002/tji.2020.1238
dc.identifier.urihttps://hdl.handle.net/20.500.12939/255
dc.identifier.volume8en_US
dc.identifier.wosWOS:000604314000003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorAdaklı Aksoy, Başak
dc.language.isotr
dc.publisherTurkish Soc Immunologyen_US
dc.relation.ispartofTurkish Journal of Immunology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBera-Thalassemiaen_US
dc.subjectStem Cell Transplantationen_US
dc.subjectImmune Reconstitutionen_US
dc.titleImmune reconstitution in the patients with talasemia major after hematopoietic stem cell transplantation
dc.typeArticle

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