Genetic and circulating biomarkers of cognitive dysfunction and dementia in CKD

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dc.contributor.authorZoccali, Carmine
dc.contributor.authorMallamaci, Francesca
dc.contributor.authorWagner, Carsten A.
dc.contributor.authorUnwin, Robert
dc.contributor.authorNedergaard, Maiken
dc.contributor.authorHafez, Gaye
dc.contributor.authorMalyszko, Jolanta
dc.contributor.authorPepin, Marion
dc.contributor.authorMassy, Ziad
dc.contributor.authorPaolisso, Giuseppe
dc.contributor.authorRemuzzi, Giuseppe
dc.contributor.authorCapasso, Giovambattista B.
dc.contributor.authorCONNECT Action (Cognitive Decline in Nephro-Neurology European Cooperative Target) collaborators
dc.date.accessioned2025-05-27T05:44:41Z
dc.date.available2025-05-27T05:44:41Z
dc.date.issued2025
dc.departmentFakülteler, Eczacılık Meslek Bilimleri Bölümü, Farmakoloji Ana Bilim Dalı
dc.description.abstractChronic kidney disease (CKD) is commonly accompanied by cognitive dysfunction and dementia, which, in turn, increase the risk of hospitalization, cardiovascular events and death. Over the last 30 years, only four studies focused on genetic markers of cognitive impairment in CKD and kidney failure (KF), indicating a significant gap in research. These studies suggest potential genetic predispositions to cognitive decline in CKD patients but also underscore the necessity for more comprehensive studies. Seventeen reports have established connections between cognitive function and kidney disease markers such as estimated glomerular filtration rate (eGFR), Cystatin C and albuminuria. A rapid eGFR decline has been associated with cognitive deterioration and vascular dementia, and mild to moderate eGFR reductions with diminished executive function in elderly men. Various biomarkers have been associated to Alzheimer’s disease or dementia in CKD and KF. These include amyloid beta and phosphorylated tau proteins, uremic toxins, gut microbiota, metabolic indicators, hypertension, endothelial dysfunction, vitamins and inflammation. However, the causal relevance of these associations remains unclear. Overall, the available evidence points to a complex interplay between the different biomarkers and cognitive health in CKD patients, underscoring the need for more research to elucidate these relationships.
dc.description.sponsorshipFunding agency: European Cooperation in Science and Technology (COST) Grant number: COST ACTION CA19127
dc.identifier.citationZoccali, C., Mallamaci, F., Wagner, C. A., Unwin, R., Nedergaard, M., Hafez, G., ... & Capasso, G. B. (2025). Genetic and circulating biomarkers of cognitive dysfunction and dementia in CKD. Nephrology Dialysis Transplantation, 40(Supplement_2), ii64-ii75.
dc.identifier.doi10.1093/ndt/gfae259
dc.identifier.endpageii75
dc.identifier.issn0931-0509
dc.identifier.issn1460-2385
dc.identifier.issueSupplement_2
dc.identifier.pmid40080085
dc.identifier.scopus2-s2.0-105000430523
dc.identifier.scopusqualityQ1
dc.identifier.startpageii64
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5757
dc.identifier.volume40
dc.identifier.wosWOS:001443929700007
dc.identifier.wosqualityQ1
dc.indekslendigikaynakPubMed
dc.institutionauthorHafez, Gaye
dc.language.isoen
dc.relation.ispartofNephrology, Dialysis, Transplantation
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectcirculating biomarkers
dc.subjectCKD
dc.subjectcognitive impairment
dc.subjectdementia
dc.subjectgenetic biomarkers
dc.titleGenetic and circulating biomarkers of cognitive dysfunction and dementia in CKD
dc.typeOther

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