Insights from CD71 presentation and serum lipid peroxidation in myasthenia gravis - A small cohort study

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dc.contributor.authorÇağlayan, Sinem Tuncer
dc.contributor.authorElibol, Birsen
dc.contributor.authorSevercan, Feride
dc.contributor.authorGürsoy, Esra Başar
dc.contributor.authorTiftikçioğlu, Bedile İrem
dc.contributor.authorGüngördü Dalar, Zeynep
dc.contributor.authorÇelik, Ceren
dc.contributor.authorDai, Ayşe Suna
dc.contributor.authorKaraçam, Sevinç
dc.date.accessioned2024-08-05T09:18:52Z
dc.date.available2024-08-05T09:18:52Z
dc.date.issued2024en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri, Biyofizik Ana Bilim Dalıen_US
dc.description.abstractMyasthenia gravis (MG) is a multifaceted autoimmune disorder affecting the postsynaptic neuromuscular junction. In this study, we examined CD4+ and CD8+ T lymphocyte levels and ratios within peripheral blood mononuclear cells (PBMCs) in MG patients. Additionally, we assessed lymphocytes for the expression of CD71, which functions as a transferrin receptor mediating the uptake of iron into the cells. Building on recent discussions regarding CD20 depletion treatments in MG, we also scrutinized lymphocytes for CD20 expression. Comparative analyses were conducted among healthy controls, newly diagnosed MG patients, those undergoing pyridostigmine treatment alone, and MG patients receiving combination therapies. In the patients, the ratio of CD3+CD4+ T lymphocytes to CD3+ T lymphocytes was found to be decreased compared to the healthy controls, while the ratio of CD3+CD8+ cells to CD3+CD4+ cells increased. An increase in the percentage of CD71-expressing lymphocytes was observed in MG patients compared to the healthy control group, while CD20+ lymphocytes exhibited no statistical changes. Moreover, heightened serum lipid peroxidation levels were found in MG patients. These results suggest a possible relationship between iron metabolism, levels of CD71-expressing cells, and lipid peroxidation in MG. Conversely, pyridostigmine treatment reduced the levels of CD71-expressing cells and lipid peroxidation, suggesting potential immunomodulatory and antioxidant impacts of pyridostigmine in MG, either directly or indirectly.en_US
dc.identifier.citationÇağlayan, S. T., Elibol, B., Severcan, F., Gürsoy, E. B., Tiftikçioğlu, Z. G., Çelik, C., Dai, A. S., Karaçam, S. (2024). Insights from CD71 presentation and serum lipid peroxidation in myasthenia gravis - A small cohort study. International Immunopharmacology. 10.1016/j.intimp.2024.112787en_US
dc.identifier.issn1567-5769
dc.identifier.issn1878-1705
dc.identifier.scopus2-s2.0-85200111354
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4790
dc.identifier.wosWOS:001285947100001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSevercan, Feride
dc.institutionauthorGüngördü Dalar, Zeynep
dc.institutionauthorÇelik, Ceren
dc.language.isoen
dc.relation.ispartofInternational Immunopharmacology
dc.relation.isversionof10.1016/j.intimp.2024.112787en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCD71en_US
dc.subjectFerroptosisen_US
dc.subjectIronen_US
dc.subjectLipid peroxidationen_US
dc.subjectMyasthenia gravisen_US
dc.subjectPyridostigmineen_US
dc.titleInsights from CD71 presentation and serum lipid peroxidation in myasthenia gravis - A small cohort study
dc.typeArticle

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