Preparation and evaluation of Poly(lactic acid)/Poly(vinyl alcohol) nanoparticles using the quality by design approach
Yükleniyor...
Dosyalar
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The aim of the study was to prepare and evaluate
the potential use of poly(lactic acid)/poly(vinyl alcohol) (PLA/
PVA) nanoparticle formulations as a drug delivery system. The
nanoparticle formulations were successfully developed by the
double emulsification/solvent evaporation method. The developed
formulations were optimized using the quality by design approach
of the ICH Q8 (Pharmaceutical Development) guideline. In the
studies, the effects of emulsifying devices, evaporation technique,
centrifugation effect, and polymer concentrations on the
physicochemical parameters of the formulations were investigated
to obtain the best results. Furthermore, the prepared formulations
were evaluated for clarity, particle size, distribution, zeta potential,
surface and morphological features, preparation efficiency, and long-term stability. Based on the obtained results, the nanoparticle
formulation containing 12.5% PLA, 1% primer, and seconder PVA has a suitable particle size (181.7 ± 2.194 nm) and distribution
(0.104 ± 0.049), zeta potential (−0.88 ± 0.45 mV), and high preparation efficiency (65.38%), and nanoparticles were spherical, had
a smooth surface, and were stable up to 12 months. In conclusion, this novel formulation can be used as a potential drug delivery
system.
Açıklama
Anahtar Kelimeler
Poly(Lactic Acid)/Poly(Vinyl Alcohol) (PLA/ PVA) Nanoparticle Formulations
Kaynak
ACS Omega
WoS Q Değeri
Q2
Scopus Q Değeri
Cilt
7
Sayı
38
Künye
Ekinci, M., Yeğen, G., Aksu, B., İlem-Özdemir, D. (2022). Preparation and evaluation of Poly(lactic acid)/Poly(vinyl alcohol) nanoparticles using the quality by design approach. ACS omega, 7(38), 33793-33807.
