Preparation and evaluation of Poly(lactic acid)/Poly(vinyl alcohol) nanoparticles using the quality by design approach

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dc.contributor.authorEkinci, Meliha
dc.contributor.authorYeğen, Gizem
dc.contributor.authorAksu, Buket
dc.contributor.authorİlem-Özdemir, Derya
dc.date.accessioned2022-10-10T08:48:09Z
dc.date.available2022-10-10T08:48:09Z
dc.date.issued2022en_US
dc.departmentFakülteler, Eczacılık Teknolojisi Bilimleri Bölümü, Farmasötik Teknoloji Ana Bilim Dalıen_US
dc.description.abstractThe aim of the study was to prepare and evaluate the potential use of poly(lactic acid)/poly(vinyl alcohol) (PLA/ PVA) nanoparticle formulations as a drug delivery system. The nanoparticle formulations were successfully developed by the double emulsification/solvent evaporation method. The developed formulations were optimized using the quality by design approach of the ICH Q8 (Pharmaceutical Development) guideline. In the studies, the effects of emulsifying devices, evaporation technique, centrifugation effect, and polymer concentrations on the physicochemical parameters of the formulations were investigated to obtain the best results. Furthermore, the prepared formulations were evaluated for clarity, particle size, distribution, zeta potential, surface and morphological features, preparation efficiency, and long-term stability. Based on the obtained results, the nanoparticle formulation containing 12.5% PLA, 1% primer, and seconder PVA has a suitable particle size (181.7 ± 2.194 nm) and distribution (0.104 ± 0.049), zeta potential (−0.88 ± 0.45 mV), and high preparation efficiency (65.38%), and nanoparticles were spherical, had a smooth surface, and were stable up to 12 months. In conclusion, this novel formulation can be used as a potential drug delivery system.en_US
dc.identifier.citationEkinci, M., Yeğen, G., Aksu, B., İlem-Özdemir, D. (2022). Preparation and evaluation of Poly(lactic acid)/Poly(vinyl alcohol) nanoparticles using the quality by design approach. ACS omega, 7(38), 33793-33807.en_US
dc.identifier.endpage33807en_US
dc.identifier.issue38en_US
dc.identifier.startpage33793en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2977
dc.identifier.volume7en_US
dc.identifier.wosWOS:000862766100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorYeğen, Gizem
dc.institutionauthorAksu, Buket
dc.language.isoen
dc.relation.ispartofACS Omega
dc.relation.isversionof10.1021/acsomega.2c02141en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPoly(Lactic Acid)/Poly(Vinyl Alcohol) (PLA/ PVA) Nanoparticle Formulationsen_US
dc.titlePreparation and evaluation of Poly(lactic acid)/Poly(vinyl alcohol) nanoparticles using the quality by design approach
dc.typeArticle

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