B7-H3 : A useful emerging diagnostic marker for colon cancer

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dc.contributor.authorBostancı, Özgür
dc.contributor.authorSayın, Pınar
dc.contributor.authorKızıltan, Remzi
dc.contributor.authorAlgül, Şermin
dc.contributor.authorAydın, Mehmet Akif
dc.contributor.authorKemik, Özgür
dc.date.accessioned2023-01-15T08:11:45Z
dc.date.available2023-01-15T08:11:45Z
dc.date.issued2022en_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü,Genel Cerrahi Ana Bilim Dalıen_US
dc.description.abstractBackground: Colon cancer is the second most common malignancy causing the majority of cancer-related deaths. B7-H3 concentrations have drawn major interest as possible diagnostic biomarkers of cancer. The aim of this study was to measure the preoperative serum B7-H3 levels and to determine those that are replaced in colon cancer. Method: We measured preoperative serum B7-H3 concentrations of 90 patients aged 57-69 years diagnosed with colon cancer and 50 age-matched healthy individuals. B7-H3 levels were determined using the sandwich enzyme-linked immunosorbent assay (ELISA). Patients were categorized by stage based on the TNM staging system, and the serum levels of B7-H3 were compared between patients with different TNM stages. Result: No statistically significant difference was found between the patient and control groups in terms of age and gender. Preoperative serum B7-H3 levels were statistically significantly higher in patients with colon cancer than in the healthy group (p < 0.001). Preoperative serum B7-H3 concentration of the stage IV patients was significantly higher than those of the patients with stage I and stage II disease. In addition, higher serum B7-H3 levels were associated with lymph node status and distant metastasis in colon cancer. Conclusion: We showed that B7-H3 is highly expressed in colon cancer and can be used as a candidate diagnostic biomarker and a potential target in colon cancer in future.en_US
dc.identifier.citationBostancı, O., Sayın, P., Kızıltan, R., Algül, S., Aydın, M. A., & Kemik, O. (2022). B7-H3 : A useful emerging diagnostic marker for colon cancer. BioMed Research International, 2022.en_US
dc.identifier.scopus2-s2.0-85145645651
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/20.500.12939/3184
dc.identifier.wosWOS:000917292900005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAydın, Mehmet Akif
dc.institutionauthorKemik, Özgür
dc.language.isoen
dc.relation.ispartofBioMed Research International
dc.relation.isversionof10.1155/2022/1523338en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectColon Canceren_US
dc.subjectB7-H3 Concentrationsen_US
dc.titleB7-H3 : A useful emerging diagnostic marker for colon cancer
dc.typeArticle

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