Chemical components of thymbra spicata subsp. spicata l. essential oil and its in vitro physiological effects on human origin cell lines
Yükleniyor...
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Thymbra spicata subsp. spicata L. is a member of the Lamiaceae family, which is used in Türkiye
against various health issues among other uses. The main components of T. spicata essential oil (TE) were
identified as carvacrol (52.3%) and p-cymene (21.1%) using GC-FID and GC/MS. The in vitro effects of TE on
Miapaca-2 and HUVEC cell lines were reported for the first time. The initial results showed that TE applied to
Miapaca-2 cell lines at concentrations of ≥62.18 g/mL for 48 hours could reduce cell growth and induce
apoptosis. The application of relatively high concentrations of TE (≥82.91 g/mL) significantly (P<0.001)
suppressed cell growth. Administration of relatively high TE concentrations (≥82.91 g/mL) significantly
(P<0.001) suppressed cell growth. Concentrations of TE lower than 20.73 g/mL did not affect the viability of the
HUVEC cell line in 48 hours. The IC50 value for Miapaca-2 cells was 62.18 µg/mL, and HUVEC cells’ IC50
value was 263.97 µg/mL for 48h. The number of apoptotic cells in Miapaca-2 (55±5%) and HUVEC
(38.33±6%) were significantly higher (P<0.001). Significantly lower migration rates (P<0.001) were seen for
Miapaca-2 (52±5%) and HUVEC cell lines (64±1.67%).
Açıklama
Anahtar Kelimeler
Thymbra Spicata Subsp. Spicata, Cancer, Apoptosis, Wound-Healing, Cellular-Migration, Proliferation
Kaynak
Records of Natural Products
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
17
Sayı
4
Künye
Nath, E. Ö., Gündoğan, G. İ., & Kartal, M. (2023). Chemical components of thymbra spicata subsp. spicata l. essential oil and its in vitro physiological effects on human origin cell lines. Records of Natural Products, 17(4), 628-647.
