Chemical components of thymbra spicata subsp. spicata l. essential oil and its in vitro physiological effects on human origin cell lines

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dc.contributor.authorNath, Ebru Özdemir
dc.contributor.authorGündoğan, Gül I.
dc.contributor.authorKartal, Murat
dc.date.accessioned2023-05-31T11:32:14Z
dc.date.available2023-05-31T11:32:14Z
dc.date.issued2023en_US
dc.departmentFakülteler, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Botanik Ana Bilim Dalıen_US
dc.description.abstractThymbra spicata subsp. spicata L. is a member of the Lamiaceae family, which is used in Türkiye against various health issues among other uses. The main components of T. spicata essential oil (TE) were identified as carvacrol (52.3%) and p-cymene (21.1%) using GC-FID and GC/MS. The in vitro effects of TE on Miapaca-2 and HUVEC cell lines were reported for the first time. The initial results showed that TE applied to Miapaca-2 cell lines at concentrations of ≥62.18 g/mL for 48 hours could reduce cell growth and induce apoptosis. The application of relatively high concentrations of TE (≥82.91 g/mL) significantly (P<0.001) suppressed cell growth. Administration of relatively high TE concentrations (≥82.91 g/mL) significantly (P<0.001) suppressed cell growth. Concentrations of TE lower than 20.73 g/mL did not affect the viability of the HUVEC cell line in 48 hours. The IC50 value for Miapaca-2 cells was 62.18 µg/mL, and HUVEC cells’ IC50 value was 263.97 µg/mL for 48h. The number of apoptotic cells in Miapaca-2 (55±5%) and HUVEC (38.33±6%) were significantly higher (P<0.001). Significantly lower migration rates (P<0.001) were seen for Miapaca-2 (52±5%) and HUVEC cell lines (64±1.67%).en_US
dc.identifier.citationNath, E. Ö., Gündoğan, G. İ., & Kartal, M. (2023). Chemical components of thymbra spicata subsp. spicata l. essential oil and its in vitro physiological effects on human origin cell lines. Records of Natural Products, 17(4), 628-647.en_US
dc.identifier.endpage647en_US
dc.identifier.issn1307-6167
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85167343676
dc.identifier.scopusqualityQ2
dc.identifier.startpage628en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/3497
dc.identifier.volume17en_US
dc.identifier.wosWOS:000967234600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorNath, Ebru Özdemir
dc.language.isoen
dc.relation.ispartofRecords of Natural Products
dc.relation.isversionof10.25135/rnp.387.23.01.2671en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThymbra Spicata Subsp. Spicataen_US
dc.subjectCanceren_US
dc.subjectApoptosisen_US
dc.subjectWound-Healingen_US
dc.subjectCellular-Migrationen_US
dc.subjectProliferationen_US
dc.titleChemical components of thymbra spicata subsp. spicata l. essential oil and its in vitro physiological effects on human origin cell lines
dc.typeArticle

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