Active matrix metalloproteinase-8 and interleukin-6 detect periodontal degeneration caused by radiotherapy of head and neck cancer: A pilot study

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dc.contributor.authorKeskin, Mutlu
dc.contributor.authorLahteenmaki, Hanna
dc.contributor.authorRathnayake, Nilminie
dc.contributor.authorRaisanen, Ismo T.
dc.contributor.authorTervahartiala, Taina
dc.contributor.authorParnanen, Pirjo
dc.contributor.authorSorsa, Timo
dc.date.accessioned2021-05-15T11:33:17Z
dc.date.available2021-05-15T11:33:17Z
dc.date.issued2020
dc.departmentDiş Hekimliği Fakültesien_US
dc.descriptionRaisanen, Ismo/0000-0001-5821-5299; Hagstrom, Jaana/0000-0001-6079-7881; Heikkila, Pia/0000-0002-5925-1993; Gursoy, Ulvi Kahraman/0000-0002-1225-5751
dc.description.abstractBackground: This cohort study investigated the role of the active matrix metalloproteinase-8 (aMMP-8) and interleukin-6 (IL-6) as oral fluid biomarkers for monitoring the periodontal degeneration occurring in head and neck cancer (HNC) patients treated by radiotherapy. Research design and methods: Eleven patients, aged 28-74, diagnosed with HNC were included in the study. Complete periodontal and oral examinations were performed pre-radiotherapy and 1 month after radiotherapy. Mouthrinse samples (pre-radiotherapy, after 6 weeks of radiotherapy and 1 month after radiotherapy) were assayed by aMMP-8 point-of-care-kit (PerioSafe (R)/ORALyzer (R)) for aMMP-8 and ELISA for IL-6. Results: HNC radiotherapy had a deteriorating impact on the periodontium and a significant impact on periodontal biomarkers aMMP-8 and IL-6 and increased their levels in mouthrinse. Clinical-attachment-loss (CAL) (site of greatest loss: mean = 1.7 mm, range = 1-3 mm) corresponding to rapid progression of periodontitis. There was a positive repeated measures correlation (rmcorr = 0.667) between the aMMP-8 and IL-6 levels. Conclusions: Elevated aMMP-8 levels were observed 1 month after radiotherapy among some HNC patients suggesting a prolonged increased susceptibility to further periodontal tissue destruction. Currently available aMMP-8 point-of-care testing could be useful to monitor and assess quantitatively online and real-time the risk of deterioration of periodontal health during HNC radiotherapy.en_US
dc.description.sponsorshipHelsinki University Hospital, Helsinki, Finland [TYH2016251, TYH2017251, TYH2018229, TYH2019319, Y1014SL017, Y1014SL018, Y1014SULE1]; Karolinska Institute, Stockholm, SwedenKarolinska Instituteten_US
dc.description.sponsorshipThis research was funded by the Helsinki University Hospital, Helsinki, Finland (grant numbers: TYH2016251, TYH2017251, TYH2018229, TYH2019319, Y1014SL017, Y1014SL018, Y1014SULE1), and the Karolinska Institute, Stockholm, Sweden. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.en_US
dc.identifier.doi10.1080/14789450.2020.1858056
dc.identifier.endpage784en_US
dc.identifier.issn1478-9450
dc.identifier.issn1744-8387
dc.identifier.issue10en_US
dc.identifier.pmid33406924
dc.identifier.scopus2-s2.0-85099187563
dc.identifier.scopusqualityQ2
dc.identifier.startpage777en_US
dc.identifier.urihttps://doi.org/10.1080/14789450.2020.1858056
dc.identifier.urihttps://hdl.handle.net/20.500.12939/121
dc.identifier.volume17en_US
dc.identifier.wosWOS:000605385500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKeskin, Mutlu
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofExpert Review of Proteomics
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectaMMP-8en_US
dc.subjectHead And Neck Canceren_US
dc.subjectIl-6en_US
dc.subjectPeriodontitisen_US
dc.subjectPoint Of Care Technologyen_US
dc.subjectRadiotherapyen_US
dc.titleActive matrix metalloproteinase-8 and interleukin-6 detect periodontal degeneration caused by radiotherapy of head and neck cancer: A pilot study
dc.typeReview Article

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