Foam-based antibacterial hydrogel composed of carboxymethyl cellulose/polyvinyl alcohol/cerium oxide nanoparticles for potential wound dressing

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dc.contributor.authorOrhan, Burcu
dc.contributor.authorKaradeniz, Duygu
dc.contributor.authorKalaycıoğlu, Zeynep
dc.contributor.authorKaygusuz, Hakan
dc.contributor.authorTorlak, Emrah
dc.contributor.authorErim, F. Bedia
dc.date.accessioned2024-12-23T09:41:49Z
dc.date.available2024-12-23T09:41:49Z
dc.date.issued2024en_US
dc.departmentFakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Temel Bilimler Bölümüen_US
dc.description.abstractFoam-based wound dressing materials produced by dispersing gas phases in a polymeric material are soft, adapt to the body shape, and allow the absorption of wound exudate due to their porous structure. Most of these formulations are based on synthetic substances such as polyurethane. However, biopolymers have entered the field as a new player thanks to their biocompatible and sustainable nature. Incorporating biopolymers in formulations is gaining interest in scientific literature, and we extend this approach by adding antibacterial cerium oxide nanoparticles to biopolymer formulation. We introduce a novel biopolymer composite of carboxymethyl cellulose (CMC), polyvinyl alcohol (PVA), and cerium oxide nanoparticles (CeO2 NPs), namely PVA-CMC@CeO2. This mixture was first foamed and then cross-linked with sodium tetraborate solution, followed by a freeze-thaw process. After the novel material's spectroscopic, structural, and morphological characterization, we investigated its swelling, drug-delivery, antibacterial, and biodegradability properties PVA-CMC@CeO2 dressing effectively inhibits Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) growth and delivers the antibiotic drug silver sulfadiazine for up to 6 h. The antibacterial properties, good swelling, and drug release profile of the blend material show promising potential in wound care applications.en_US
dc.identifier.citationOrhan, B., Karadeniz, D., Kalaycıoğlu, Z., Kaygusuz, H., Torlak, E., Erim, F. B. (2024). Foam-based antibacterial hydrogel composed of carboxymethyl cellulose/polyvinyl alcohol/cerium oxide nanoparticles for potential wound dressing. International Journal of Biological Macromolecules. 10.1016/j.ijbiomac.2024.138924en_US
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.scopus2-s2.0-85212974468
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5091
dc.identifier.wosWOS:001394615900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorOrhan, Burcu
dc.institutionauthorKaygusuz, Hakan
dc.language.isoen
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.relation.isversionof10.1016/j.ijbiomac.2024.138924en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibacterialen_US
dc.subjectBiopolymeren_US
dc.subjectDrug releaseen_US
dc.subjectNanoceriaen_US
dc.subjectWound healingen_US
dc.titleFoam-based antibacterial hydrogel composed of carboxymethyl cellulose/polyvinyl alcohol/cerium oxide nanoparticles for potential wound dressing
dc.typeArticle

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