The structural effects of Vitamin A deficiency on biological macromolecules due to ethanol consumption and withdrawal: An FTIR study with chemometrics

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dc.contributor.authorElibol, Birsen
dc.contributor.authorSevercan, Mete
dc.contributor.authorJakubowska-Dogru, Ewa
dc.contributor.authorDursun, Ilknur
dc.contributor.authorSevercan, Feride
dc.date.accessioned2022-04-25T07:12:03Z
dc.date.available2022-04-25T07:12:03Z
dc.date.issued2022en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri, Biyofizik Ana Bilim Dalıen_US
dc.description.abstractThe structural effects of vitamin A-deficiency were examined on the molecular profiles of biomolecules of male rat hippocampus during prolonged ethanol intake/withdrawal using FT-IR spectroscopy coupled with chemometrics. Liquid ethanol diet with/without vitamin A was maintained to adult rats for 3-months. The rats were decapitated at different ethanol withdrawal times and FT-IR spectra were obtained. Ethanol consumption/withdrawal produced significant changes in proteins' conformations, while having insignificant structural effects on lipids. In vitamin A deficiency, ethanol produced structural changes in lipids by lipid ordering especially in the early-ethanol withdrawal. Furthermore, an increase in lipid and protein content, saturated/unsaturated lipid ratio, a decrease in nucleic acids content and decrease in membrane fluidity were observed. These changes were less severe in the presence of Vitamin A. This study is clinically important for individuals with vitamin A deficiency because they have to be more cautious when consuming alcohol to protect themselves from cognitive dysfunctions.en_US
dc.identifier.citationElibol, B., Severcan, M., Jakubowska‐Dogru, E., Dursun, I., & Severcan, F. (2022). The structural effects of Vitamin A deficiency on biological macromolecules due to ethanol consumption and withdrawal: An FTIR study with chemometrics. Journal of Biophotonics.en_US
dc.identifier.scopus2-s2.0-85127955675
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2374
dc.identifier.wosWOS:000780638400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSevercan, Feride
dc.language.isoen
dc.relation.ispartofJournal of Biophotonics
dc.relation.isversionof10.1002/jbio.202100377en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFT-IR Spectroscopyen_US
dc.subjectMale Rat Hippocampusen_US
dc.subjectVitamin A Deficiencyen_US
dc.titleThe structural effects of Vitamin A deficiency on biological macromolecules due to ethanol consumption and withdrawal: An FTIR study with chemometrics
dc.typeArticle

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