Investigation of APOE2 rs7412 and APOA2 rs5082, APOA5 rs662799 and MTHFR rs1801133 Polymorphisms in Diabetic Obese and Non-Obese Diabetic Groups in Turkey

Basit Öğe Kaydı
dc.contributor.authorÖzyavuz, M. K.
dc.contributor.authorDurak, S.
dc.contributor.authorÇelik, F.
dc.contributor.authorAksoyer Sezgin, S.B.
dc.contributor.authorGürol, A.O.
dc.contributor.authorDoğan, Z.
dc.contributor.authorZeybek, U.
dc.date.accessioned2025-08-14T17:33:02Z
dc.date.available2025-08-14T17:33:02Z
dc.date.issued2025
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, İlk ve Acil Yardım Programı
dc.description.abstractAbstract: Obesity caused by an abnormal increase in adiposyte, is linked to type 2 diabetes. Diabetes is a metabolic-disease that is caused by insulin-deficiency. Type 2 diabetes is a serious implication of obesity and genetic polymorphisms. Apolipoprotein E2 (APOE2)(rs7412), Apolipoprotein A2 (APOA2) (rs5082), Apolipoprotein A5 (APOA5) (rs662799), Methylenetetrahydrofolate reductase (MTHFR) (rs1801133) polymorphisms which were determined to play role in the development of obesity and diabetes, were evaluated with the RT-qPZR in the study. We included 99 diabetic obese and 99 diabetic non-obese people. We investigated the effect of obesity on variants of all gene polymorphisms in diabetic patients. As a result, APOA2, APOE2 polymorphisms were significant, APOA5, MTHFR polymorphisms were not significant in genotype/allele frequency between groups. APOA2 CC-homozygous carriers had high low-density-lipoprotein-c, glucose, body-mass-index in diabetic-obese patients. APOE2 C-allele carriers had significantly high-Triglyceride and low high-density-lipoprotein versus TT-genotype in non-obese diabetic patients. The present study was first in the Turkey population and evaluates the polymorphisms of genes indicated in diabetic patients.
dc.identifier.citationOzyavuz, M. K., Durak, S., Celik, F., Aksoyer Sezgin, S. B., Gurol, A. O., Dogan, Z., & Zeybek, U. (2025). Investigation of APOE2 rs7412 and APOA2 rs5082, APOA5 rs662799 and MTHFR rs1801133 Polymorphisms in Diabetic Obese and Non-Obese Diabetic Groups in Turkey. Russian Journal of Genetics, 61(5), 588-595. 10.1134/S1022795425700115
dc.identifier.doi10.1134/S1022795425700115
dc.identifier.endpage595
dc.identifier.issn1022-7954
dc.identifier.issn1608-3369
dc.identifier.issue5
dc.identifier.scopus2-s2.0-105007944609
dc.identifier.scopusqualityQ4
dc.identifier.startpage588
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5883
dc.identifier.volume61
dc.identifier.wosWOS:001506401600010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorDoğan, Z.
dc.language.isoen
dc.publisherPleiades Publishing
dc.relation.ispartofRussian Journal of Genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAPOA2
dc.subjectAPOA5
dc.subjectAPOE2
dc.subjectdiabetes
dc.subjectMTHFR
dc.titleInvestigation of APOE2 rs7412 and APOA2 rs5082, APOA5 rs662799 and MTHFR rs1801133 Polymorphisms in Diabetic Obese and Non-Obese Diabetic Groups in Turkey
dc.typeArticle

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Sağlık Hizmetleri Meslek Yüksekokulu Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu