The Cappadocia mesothelioma epidemic: Its influence in Turkey and abroad

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dc.contributor.authorEmri, Salih A.
dc.date.accessioned2021-05-15T12:36:38Z
dc.date.available2021-05-15T12:36:38Z
dc.date.issued2017
dc.departmentTıp Fakültesien_US
dc.description.abstractThe epidemic of mesothelioma in Cappadocia, Turkey, is unprecedented in medical history. In three Cappadocian villages, Karain, Tuzkoy and "old" Sarihidir, about 50% of all deaths (including neonatal deaths and traffic fatalities) have been caused by mesothelioma. No other epidemic in medical history has caused such a high incidence of death. This is even more unusual when considering that (I) epidemics are caused by infectious agents, not cancer, and (II) mesothelioma is a rare cancer. World-wide mesothelioma incidence varies between 1/10(6) in areas with no asbestos industry to about 10-30/10(6) in areas with asbestos industry. This article reviews how the mesothelioma epidemic was discovered in Cappadocia by Dr. Baris (my mentor), how we initially linked the epidemic to erionite exposure, and later (with Dr. Carbone) to the interaction between genetic predisposition and environmental exposure. Our team's work had an important positive impact on the lives of those living in Cappadocia and also in many genetically predisposed families living around the world. I will discuss how the work that started in three remote Cappadocian villages led to the award of a NCI P01 grant to support our studies. Our studies proved that genetics modulates mineral fiber carcinogenesis and led to the discovery that carriers of germline BAP1 mutations have a very high risk of developing mesothelioma and other malignancies. A new, very active field of research developed following our discoveries to elucidate the mechanism by which BAP1 modulates mineral fiber carcinogenesis as well as to identify additional genes that when mutated increase the risk of mesothelioma and other environmentally related cancers. I am the only surviving member of this research team who saw all the phases of this research and I believe it is important to provide an accurate report, which hopefully will inspire others.en_US
dc.identifier.doi10.21037/atm.2017.04.06
dc.identifier.issn2305-5839
dc.identifier.issn2305-5847
dc.identifier.issue11en_US
dc.identifier.pmid28706907
dc.identifier.scopus2-s2.0-85020832080
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.21037/atm.2017.04.06
dc.identifier.urihttps://hdl.handle.net/20.500.12939/354
dc.identifier.volume5en_US
dc.identifier.wosWOS:000408645200011
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorEmri, Salih A.
dc.language.isoen
dc.publisherAme Publ Coen_US
dc.relation.ispartofAnnals of Translational Medicine
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectErioniteen_US
dc.subjectBAP1en_US
dc.subjectEnvironmental Mesotheliomaen_US
dc.subjectGene And Environment Interactionen_US
dc.titleThe Cappadocia mesothelioma epidemic: Its influence in Turkey and abroad
dc.typeReview Article

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