Multifaceted Therapeutic Potential of Plant-Derived Exosomes: Immunomodulation, Anticancer, Anti-Aging, Anti-Melanogenesis, Detoxification, and Drug Delivery

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dc.authorid0000-0002-2482-0359
dc.authorid0000-0002-0105-919X
dc.authorid0000-0003-4683-074X
dc.contributor.authorKarabay, Arzu Zeynep
dc.contributor.authorBara, Jaleh
dc.contributor.authorHekmatshoar, Yalda
dc.contributor.authorSaadat, Yalda Rahbar
dc.date.accessioned2025-06-12T06:13:24Z
dc.date.available2025-06-12T06:13:24Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri, Tıbbi Biyoloji Ana Bilim Dalı
dc.description.abstractMost eukaryotic and prokaryotic cells have the potential to secrete a group of structures/membrane-bound organelles, collectively referred to as extracellular vesicles (EVs), which offer several advantages to producer/receiver cells. This review provides an overview of EVs from plant sources with emphasis on their health-promoting potential and possible use as therapeutic agents. This review highlights the essential biological effects of plant-derived extracellular vesicles, including immune modulation, anticancer activities, protection against chemical toxicity and pathogens, as well as anti-aging, anti-melanogenesis, and anti-arthritic effects, along with ongoing clinical studies. Evidence revealed that plant-derived EVs' contents exert their beneficial properties through regulating important signaling pathways by transferring miRNAs and other components. Taken all together, the data proposed that plant-derived EVs can be utilized as nutritional compounds and therapeutic agents, such as drug carriers. However, this emerging research area requires further in vitro/in vivo studies and clinical trials to determine the exact underlying mechanisms of EVs' positive health effects in treating various diseases.
dc.identifier.citationKarabay, A. Z., Barar, J., Hekmatshoar, Y., & Rahbar Saadat, Y. (2025). Multifaceted therapeutic potential of plant-derived exosomes: immunomodulation, anticancer, anti-aging, anti-melanogenesis, detoxification, and drug delivery. Biomolecules, 15(3), 394.
dc.identifier.doi10.3390/biom15030394
dc.identifier.issn2218-273X
dc.identifier.issue3
dc.identifier.pmid40149930
dc.identifier.scopus2-s2.0-105001400896
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5772
dc.identifier.volume15
dc.identifier.wosWOS:001452915000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakPubMed
dc.institutionauthorHekmatshoar, Yalda
dc.institutionauthorid0000-0003-4683-074X
dc.language.isoen
dc.relation.ispartofBiomolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectanti-aging
dc.subjectanti-melanogenesis
dc.subjectanticancer
dc.subjectdetoxification
dc.subjectdrug delivery
dc.subjectexosome
dc.subjectimmunomodulation
dc.subjectplant-derived extracellular vesicle
dc.subjecttherapy
dc.titleMultifaceted Therapeutic Potential of Plant-Derived Exosomes: Immunomodulation, Anticancer, Anti-Aging, Anti-Melanogenesis, Detoxification, and Drug Delivery
dc.typeOther

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