Rapid diagnosis of malignant pleural mesothelioma and its discrimination from lung cancer and benign exudative effusions using blood serum

Basit Öğe Kaydı
dc.contributor.authorYonar, Dilek
dc.contributor.authorSevercan, Mete
dc.contributor.authorGurbanov, Rafig
dc.contributor.authorSandal, Abdulsamet
dc.contributor.authorYılmaz, Ülkü
dc.contributor.authorEmri, Salih
dc.contributor.authorSevercan, Feride
dc.date.accessioned2022-07-05T12:35:37Z
dc.date.available2022-07-05T12:35:37Z
dc.date.issued2022en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri, Biyofizik Ana Bilim Dalıen_US
dc.description.abstractMalignant pleural mesothelioma (MPM), an aggressive cancer associated with exposure to fibrous minerals, can only be diagnosed in the advanced stage because its early symptoms are also connected with other respiratory diseases. Hence, understanding the molecular mechanism and the discrimination of MPM from other lung diseases at an early stage is important to apply effective treatment strategies and for the increase in survival rate. This study aims to develop a new approach for characterization and diagnosis of MPM among lung diseases from serum by Fourier transform infrared spectroscopy (FTIR) coupled with multivariate analysis. The detailed spectral characterization studies indicated the changes in lipid biosynthesis and nucleic acids levels in the malignant serum samples. Furthermore, the results showed that healthy, benign exudative effusion, lung cancer, and MPM groups were successfully separated from each other by applying principal component analysis (PCA), support vector machine (SVM), and especially linear discriminant analysis (LDA) to infrared spectra.en_US
dc.identifier.citationYonar, D., Severcan, M., Gurbanov, R., Sandal, A., Yılmaz, U., Emri, S., Severcan, F. (2022). Rapid diagnosis of malignant pleural mesothelioma and its discrimination from lung cancer and benign exudative effusions using blood serum. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1868(10).en_US
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85132845226
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2621
dc.identifier.volume1868en_US
dc.identifier.wosWOS:000826690300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSevercan, Feride
dc.language.isoen
dc.relation.ispartofBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
dc.relation.isversionof10.1016/j.bbadis.2022.166473en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMesotheliomaen_US
dc.subjectLung Canceren_US
dc.subjectBlood Serumen_US
dc.subjectSpectral Biomarkersen_US
dc.subjectATR-FTIR Spectroscopyen_US
dc.subjectMultivariate Analysisen_US
dc.titleRapid diagnosis of malignant pleural mesothelioma and its discrimination from lung cancer and benign exudative effusions using blood serum
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
1-s2.0-S0925443922001442-main.pdf
Boyut:
4.93 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Temel Tıp Bilimleri Bölümü Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu