Photoprotective effects of quercetin on photoaging-induced rats

Basit Öğe Kaydı
dc.contributor.authorKızılkan, Betül
dc.contributor.authorŞereflican, Betül
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorErdoğan Düzcü, Selma
dc.contributor.authorAltuğ, Cevher
dc.contributor.authorKızılkan, Jehat
dc.date.accessioned2024-12-23T09:46:15Z
dc.date.available2024-12-23T09:46:15Z
dc.date.issued2024en_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: Photoaging is characterised by cutaneous changes caused by exposure to ultraviolet light over time. Quercetin is a bioflavanoid with antioxidant, antineoplastic, and anti-inflammatory effects. This study investigated the therapeutic effects of topical quercetin on photoaging, a phenomenon not previously studied in ultraviolet A (UVA)-induced photoaging. Methods: A total of 40 rats were randomly categorised into 5 groups, each comprising 8 rats. A photoaging model was induced by applying UVA to the dorsal region of all rats, except for the negative control group. Topical 0.1% retinoic acid was applied to one UVA group, topical 0.3% quercetin to another UVA group, and both agents were applied in combination to yet another UVA group 5 days a week for 8 weeks. Subsequently, wrinkle values were measured, reactive oxygen species (ROS) and matrix metalloproteinase-1 (MMP-1) levels were analysed, and histopathological parameters were examined. Results: The wrinkle value of the UVA group was found to be significantly higher than that of the UVA + Quercetin group. Collagen damage was lower in the UVA + Quercetin group than in the UVA group, although this difference was not statistically significant. Compared with the UVA + Retinoic Acid group, the UVA + Quercetin group exhibited a more significant decrease in inflammation. MMP-1 values were considerably higher in the UVA + Retinoic Acid and UVA + Quercetin + Retinoic Acid groups as well as in the UVA + Quercetin group compared with the control and UVA groups. Conclusion: The present study showed that quercetin can be utilised in the treatment of photoaging, especially when combined with retinoic acid.en_US
dc.identifier.citationKizilkan, B., Sereflican, B., Cetinkaya, A., Erdogan Duzcu, S., Altug, C., Kizilkan, J. (2024). Photoprotective effects of quercetin on photoaging-induced rats. Cutaneous and Ocular Toxicology, 1-9. 10.1080/15569527.2024.2442584en_US
dc.identifier.endpage9en_US
dc.identifier.issn1556-9527
dc.identifier.issn1556-9535
dc.identifier.scopus2-s2.0-85212414474
dc.identifier.scopusqualityQ3
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5096
dc.identifier.wosWOS:001379669300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKızılkan, Jehat
dc.language.isoen
dc.relation.ispartofCutaneous and Ocular Toxicology
dc.relation.isversionof10.1080/15569527.2024.2442584en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMMP-1en_US
dc.subjectPhotoagingen_US
dc.subjectQuercetinen_US
dc.subjectRetinoic aciden_US
dc.subjectUltraviolet Aen_US
dc.titlePhotoprotective effects of quercetin on photoaging-induced rats
dc.typeArticle

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