Nanocapsules in biomedicine promises and challenges
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Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Scrivener Publishing Llc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
With the recent advances in nanotechnology, in the past decade, the ways of doing biomedicine have been reshaped considerably. Nanometer-size structures (nanoparticles, nanowires, nanocapsules, etc.) are used in biosensing, molecular imaging, diagnosis and therapies, based on their exceptionally diverse properties. Properties such as size, morphology, aggregation propensity, functionalization, biocompatibility, and biodegradability are being continuously optimized to maximize their biomedical efficacy. Among these nanostructures, nanocapsules are the next-generation approach promising to control "cellular health," by programming the release of cargo to the target cell or organ based on endogenous (e.g. enzymes and pH) or external (light, magnetic field, ultrasound) stimuli. Nanocapsules are a class of porous polymeric or inorganic particles in the nanometer range, with tunable features such as pore diameter, pore topology, diverse surface properties, and loading efficiencies that can be easily tailored to several biomedical applications. However, the use of nanocapsules in the biomedicine field is still in its infancy. Most studies have been performed in silico or in cell lines, and just very few studies have been done in animal models of disease. This chapter focuses on those studies where nanocapsules have been well characterized in vitro and in vivo, with the potential to be translated into the clinic. Moreover, this chapter also offers an overview of the recent advances in nanocapsule-based approaches for cancer therapy.
Açıklama
Kavruk, Murat/0000-0001-5331-7253; Ozalp, Veli Cengiz/0000-0002-7659-5990
Anahtar Kelimeler
Biomedicine, Nanocapsules
Kaynak
Advanced Theranostics Materials
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
