The investigation of the effects of postnatal alcohol exposure on molecular content and antioxidant capacity of mice liver tissue

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dc.contributor.authorAlgburi, Ali Forat
dc.contributor.authorDursun, İlknur
dc.contributor.authorGarip Ustaoğlu, Şebnem
dc.date.accessioned2022-10-28T07:57:32Z
dc.date.available2022-10-28T07:57:32Z
dc.date.issued2022en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.description.abstractOne of the most common causes of fetal alcohol spectrum disease (FASD) characterized with neurodevelopmental disorder and growth retardation, is the postnatal alcohol consumption. Since studies in literature are mainly focused on alcohol-induced effects on brain tissues, the molecular effects of postnatal alcohol consumption on fetal liver are not clarified yet. The aim of this study is to determine the postnatal alcohol consumption-induced structural and compositional changes on liver tissue and the antioxidant capacity of liver. Newborn mice were divided into 3 groups as control group without any treatment, alcohol group treated with 3.0 g/kg of ethanol in 0.02 ml/g of artificially enriched milk between Postnatal Days (PD) 3-20 and intragastric intubation control group which was intragastrically intubated in the same method as the alcohol group but without ethanol/milk. These postnatal days in mice refers prenatal period (third trimester) of gestation in human. The biomolecular changes were determined by ATR-FTIR spectral analysis of the samples, besides the biochemical measurement of total protein content and antioxidant capacity of liver tissue. The result of the current study shows that while there was a slight increase in total lipid content, significant decrease in unsaturated lipid and total protein contents and total antioxidant capacity of liver were observed in alcohol-treated group. Thus, it is concluded that postnatal alcohol treatment causes significant changes in tissue proteins and lipids by inducing lipid peroxidation and changes in protein conformations of the liver tissue. In addition to that alcohol consumption also reduce the antioxidant capacity of liver tissue.en_US
dc.identifier.citationAlgburi, A. F., Dursun, İ., Ustaoglu, Ş. G. (2022). The investigation of the effects of postnatal alcohol exposure on molecular content and antioxidant capacity of mice liver tissue. Life Sciences, 121102.en_US
dc.identifier.scopus2-s2.0-85141892007
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2987
dc.identifier.wosWOS:000880621100002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAlgburi, Ali Forat
dc.institutionauthorGarip Ustaoğlu, Şebnem
dc.language.isoen
dc.publisherElsevieren_US
dc.relation.ispartofLife Sciences
dc.relation.isversionof10.1016/j.lfs.2022.121102en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - İdari Personel ve Öğrencien_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectATR-FTIR Spectroscopyen_US
dc.subjectIntragastric Intubationen_US
dc.subjectLiveren_US
dc.subjectMiceen_US
dc.subjectPostnatal Alcohol Consumptionen_US
dc.subjectTotal Antioxidant Capacityen_US
dc.titleThe investigation of the effects of postnatal alcohol exposure on molecular content and antioxidant capacity of mice liver tissue
dc.typeArticle

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