Enhancing Radiotherapy Tolerance With Papaya Seed-Derived Nanoemulsions

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dc.contributor.authorSiddiqui, Muhammad Tariq
dc.contributor.authorÖlçeroğlu, Bilge
dc.contributor.authorGümüş, Zinar Pınar
dc.contributor.authorŞenışık, Ahmet Murat
dc.contributor.authorBarlas, Fırat Barış
dc.date.accessioned2025-07-04T06:53:03Z
dc.date.available2025-07-04T06:53:03Z
dc.date.issued2025
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Radyoterapi Programı
dc.description.abstractFlavonoid-rich plant materials have gained attention for their potential to reduce radiotherapy side effects. Carica papaya (CP) seeds, known for high flavonoid content, hold promise for therapeutic applications. This study explored the extraction and evaluation of two oils-sunflower oil-based papaya oil (SPO) and pure papaya oil (PPO)-and their nano emulsions (SPOE and PPOE), derived from CP seeds, for radioprotective effects. Chemical analysis using QTOF-MS revealed antioxidants and phytochemicals in the oils and emulsions. Size analysis and zeta potential measurements using dynamic light scattering (DLS) showed particle sizes of 140 ± 26.06 nm for PPOE and 293.7 ± 49.42 nm for SPOE. Post-radiation, both SPOE and PPOE significantly enhanced cell viability, with values of 72.24 ± 3.92 (p ≤ 0.001) and 75.85 ± 2.62 (p ≤ 0.001), respectively. These nanoemulsions show potential as topical agents for reducing radiation-induced tissue damage in radiotherapy. Despite the promising in vitro findings, further in vivo studies are needed to confirm the clinical relevance of these nanoemulsions. Additionally, their incorporation into sunscreen formulations could provide further protection against radiation-induced skin damage, broadening their potential applications.
dc.identifier.citationSiddiqui, M. T., Ölçeroğlu, B., Gümüş, Z. P., Şenışık, A. M., & Barlas, F. B. (2025). Enhancing Radiotherapy Tolerance With Papaya Seed‐Derived Nanoemulsions. Food Science & Nutrition, 13(4), e70145.
dc.identifier.doi10.1002/fsn3.70145
dc.identifier.issn2048-7177
dc.identifier.issue4
dc.identifier.pmid40191523
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5792
dc.identifier.volume13
dc.identifier.wosWOS:001459691600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakPubMed
dc.institutionauthorSiddiqui, Muhammad Tariq
dc.institutionauthorŞenışık, Ahmet Murat
dc.language.isoen
dc.publisherMalden
dc.relation.ispartofFood Science and Nutrition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPapaya carica
dc.subjectflovonoids
dc.subjectnanoemulsions
dc.subjectradiation‐induced tissue damage
dc.subjectradioprotective agents
dc.titleEnhancing Radiotherapy Tolerance With Papaya Seed-Derived Nanoemulsions
dc.typeArticle

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