Investigation of the protective effect of gel incorporating Eugenia jambolana leaf extract on 5-fluorouracil-induced oral mucositis: An animal study

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dc.contributor.authorAksoy, Nilay
dc.contributor.authorSen, Emine
dc.contributor.authorSukmasari, Susi
dc.contributor.authorÖzakpınar, Özlem Bingöl
dc.contributor.authorArıcıoğlu, Feyze
dc.contributor.authorYücel, Yasemin Yücel
dc.contributor.authorDumlu, Muhammet Rıdvan
dc.contributor.authorDoolaanea, Abd Almonem
dc.contributor.authorAbdulRahman, Mohammad Nasrin
dc.contributor.authorOlgac, Vakur
dc.contributor.authorBozkan, Pırıl
dc.contributor.authorOzen, Bugra
dc.date.accessioned2022-06-10T08:29:35Z
dc.date.available2022-06-10T08:29:35Z
dc.date.issued2022en_US
dc.departmentFakülteler, Eczacılık Meslek Bilimleri Bölümü, Klinik Eczacılık Ana Bilim Dalıen_US
dc.description.abstractPurpose The study aimed to evaluate the possible preventive efect of two concentrations (3 and 5% w/w) of Eugenia jambolana (EJ) extract against 5-FU-induced mucositis. Method Sixteen adult rats were separated into four groups: two control and two preventive groups. Animals in Groups 1, 2, and 3 were injected intraperitoneally with 60 mg/kg/day of 5-FU on Day 1 followed by 150 mg/kg/day on Day 5. The rats in Group 4 (negative control) were given physiological saline at the same times and doses. Furthermore, on the ffth day of the study, the cheek and sublingual mucosa were irritated by external superfcial scratches using the tip of an 18-G needle, followed by the application 15 µL of 20% acetic acid, after which 3 and 5% EJ w/w gels were applied topically for animals in Groups 2 and 3, respectively. Results The weight and the mucositis scores were recorded. Antioxidant and anti-infammatory markers and biochemical tests were analyzed. Signifcant diferences were found between the study groups in weight loss, clinical mucositis scores, mortality rates, and antioxidant and anti-infammatory parameters. Conclusion The preventive efect of 3% gel was signifcant, with no mortality rate, making it an option for preventive strategies..en_US
dc.identifier.citationAksoy, N., Sen, E., Sukmasari, S., Özakpınar, Ö. B., Arıcıoğlu, F., Yücel, Y. Y., ... & Ozan, B. (2022). Investigation of the protective effect of gel incorporating Eugenia jambolana leaf extract on 5-fluorouracil-induced oral mucositis: An animal study. Journal of Cancer Research and Clinical Oncology, 1-10.en_US
dc.identifier.endpage10en_US
dc.identifier.scopus2-s2.0-85130847543
dc.identifier.scopusqualityQ3
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2475
dc.identifier.wosWOS:000800703000002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAksoy, Nilay
dc.language.isoen
dc.relation.ispartofJournal of Cancer Research and Clinical Oncology
dc.relation.isversionof10.1007/s00432-022-04065-3en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMucositisen_US
dc.subjectChemotherapyen_US
dc.subjectEugenia Jambolanaen_US
dc.subjectAntioxidanten_US
dc.subjectAnti - infammatoryen_US
dc.subjectGelen_US
dc.titleInvestigation of the protective effect of gel incorporating Eugenia jambolana leaf extract on 5-fluorouracil-induced oral mucositis: An animal study
dc.typeArticle

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