Pregnancy and delivery in the sequel of, kidney transplantation: Single-center study of 8 years' experience

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dc.contributor.authorYüksel, Y.
dc.contributor.authorTekin, S.
dc.contributor.authorYüksel, D.
dc.contributor.authorDuman, I.
dc.contributor.authorSarıer, M.
dc.contributor.authorYücetin, L.
dc.contributor.authorDemirbaş, A.
dc.contributor.authorUğurlu, T.
dc.contributor.authorCelep, H.
dc.contributor.authorİnal, M. M.
dc.date.accessioned2021-05-15T12:36:41Z
dc.date.available2021-05-15T12:36:41Z
dc.date.issued2017
dc.departmentTıp Fakültesien_US
dc.descriptionSarier, Mehmet/0000-0002-8656-7416;
dc.description.abstractBackground. Depending on hyphothalamic, hyphophyseal, and gonadal axis dysfunction, anovulatory irregular cycles occur and the probability of pregnancy decreases in the patients with chronic kidney disease (CKD). Maternal mortality and morbidity rates are increased in CKD patients; the risk of premature delivery is 70% and the risk of preeclampsia is 40% more than normal among those with a creatine level of >2.5 mg/dL. Methods. If a pregnancy is expected in the sequel of kidney transplantation (KT), a multidisciplinary team approach should be adopted and both the gynecologist and the nephrologist should follow the patient simultaneously. Among 3883 patients who underwent KT at Antalya Medical Park Hospital Transplantion Department between November 2009 and October 2016, the records of 550 female patients between the ages of 18 and 40 years were examined retrospectively; 31 patients who complied with these criteria were included in the study group. In 6 of these patients who had an unplanned pregnancy, medical abortion was performed after the families were informed about the possible fetal anomalies caused by the use of everolimus in the first trimester, and they were excluded from the study (pregnant group). The control group consisted of 43 patients who had a KT and became pregnant, and of those who had recently undergone KT and shared similarities regarding age, CKD etiology, duration of dialysis, and number of transplants. Results. In both groups, the ages of the patients, their follow-up span and dialysis duration, tissue compatibility, age of the donor, and time elapsed until the pregnancy was analyzed, whereas in the control group, creatinine levels in the first, second, third, and fourth years after the KT were reviewed. Additionally, in the pregnant group, creatinine levels of the first, second, and third trimesters; delivery week; birth weight of the baby; APGAR scores of the first minute; postnatal creatinine levels of first, second, and third years; and prenatal, maternal, and postnatal acute rejections were reviewed. We measured the creatine clearance by use of the Cockcroft-Gault formula in the pregnancy group before pregnancy and during delivery [Cockcroft-Gault formula: (140 - age) x body weight (kg)/72 x plasma creatine level (mg/dL) x 0.85]. Conclusions. Pregnancy after KT is risky both for the mother and the baby; however, if planned and followed in coordination within an experienced center, both the pregnancy period and the birth process can occur without distress.en_US
dc.identifier.doi10.1016/j.transproceed.2017.02.002
dc.identifier.endpage550en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue3en_US
dc.identifier.pmid28340831
dc.identifier.scopus2-s2.0-85015897258
dc.identifier.scopusqualityQ3
dc.identifier.startpage546en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2017.02.002
dc.identifier.urihttps://hdl.handle.net/20.500.12939/372
dc.identifier.volume49en_US
dc.identifier.wosWOS:000398017900035
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTekin, S.
dc.language.isoen
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedings
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMedicineen_US
dc.subjectKidney Transplantationen_US
dc.subjectPregnancyen_US
dc.titlePregnancy and delivery in the sequel of, kidney transplantation: Single-center study of 8 years' experience
dc.typeArticle

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