Remineralization efficiency of three different agents on artificially produced enamel lesions: A micro-CT study

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dc.contributor.authorİlisulu, Sabiha Ceren
dc.contributor.authorGürcan, Aliye Tuğçe
dc.contributor.authorŞişmanoğlu, Soner
dc.date.accessioned2024-08-05T09:19:24Z
dc.date.available2024-08-05T09:19:24Z
dc.date.issued2024en_US
dc.departmentFakülteler, Diş Hekimliği Fakültesi, Çocuk Diş Hekimliği Ana Bilim Dalıen_US
dc.description.abstractObjective: This study aimed to assess the remineralization efficacy of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), silver diamine fluoride/potassium iodide (SDF/KI), and sodium fluoride with functionalized tricalcium phosphate (NaF/fTCP) on artificial early enamel lesion using laser fluorescence and micro-CT analysis. Methodology: On extracted impacted third molars, artificial enamel lesions were prepared. Twenty-eight specimens were randomly assigned to four groups (n = 7 per group): a control group (artificial saliva), CPP-ACP (GC Tooth Mousse), SDF/KI (Riva Star), and NaF/fTCP (Clinpro White varnish). Following the manufacturer's instructions, the remineralization agents were applied to demineralized surfaces. Laser fluorescence and micro-CT were used to evaluate the remineralization efficacy of the agents and analyzes were performed during four stages: before demineralization, after demineralization, 1st day of remineralization and 30th day of remineralization. Shapiro-Wilk test, repeated measures two-way ANOVA, and Spearman correlation tests were used for statistical analysis. A significant level of p < 0.05 was established. Results: SDF/KI significantly reduced the lesion area and lesion volume on the demineralized enamel surface after 30 days of remineralization. In the T3 period, SDF/KI increased the mineral density statistically significantly compared to the T1 period. The laser fluorescence values for all three remineralizing agents exhibited a linear decrease. A significant correlation between the fluorescence values and the mineral density was found (p = 0.01). Conclusion: All three investigated agents were showed positive remineralization efficacy on artificial enamel lesion. However, SDF/KI, containing silver diamine fluoride and potassium iodide exhibited superior than other agents in promoting remineralization. Clinical significance: Although all three remineralization agents showed positive remineralization efficacy on artificial enamel lesions, SDF had higher remineralization performance over the other two agents. SDF has potential to prevent progression of demineralization in treating children with high caries risk in the long-term.en_US
dc.identifier.citationİlisulu, S. C., Gürcan, A. T., Şişmanoğlu, S. (2024). Remineralization efficiency of three different agents on artificially produced enamel lesions: A micro-CT study. Journal of Esthetic and Restorative Dentistry, 36(11), 1536-1546. 10.1111/jerd.13292en_US
dc.identifier.endpage1546en_US
dc.identifier.issn1496-4155
dc.identifier.issn1708-8240
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-85200048934
dc.identifier.scopusqualityQ1
dc.identifier.startpage1536en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4791
dc.identifier.volume36en_US
dc.identifier.wosWOS:001281103400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorİlisulu, Sabiha Ceren
dc.language.isoen
dc.relation.ispartofJournal of Esthetic and Restorative Dentistry
dc.relation.isversionof10.1111/jerd.13292en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCPP‐ACPen_US
dc.subjectEarly enamel lesionen_US
dc.subjectRemineralizationen_US
dc.subjectSilver diamine fluorideen_US
dc.subjectSodium fluorideen_US
dc.titleRemineralization efficiency of three different agents on artificially produced enamel lesions: A micro-CT study
dc.typeArticle

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