Animal models to study cognitive impairment of chronic kidney disease

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dc.contributor.authorSilva, Pedro H. Imenez
dc.contributor.authorPepin, Marion
dc.contributor.authorFigurek, Andreja
dc.contributor.authorGutierrez-Jimenez, Eugenio
dc.contributor.authorBobot, Mickael
dc.contributor.authorIervolino, Anna
dc.contributor.authorMattace-Rosso, Francesco
dc.contributor.authorHoorn, Ewout J.
dc.contributor.authorBailey, Matthew A.
dc.contributor.authorHenaut, Lucie
dc.contributor.authorNielsen, Rikke
dc.contributor.authorFrische, Sebastian
dc.contributor.authorTrepiccione, Francesco
dc.contributor.authorHafez, Gaye
dc.contributor.authorAltunkaynak, Hande O.
dc.contributor.authorEndlich, Nicole
dc.contributor.authorUnwin, Robert
dc.contributor.authorCapasso, Giovambattista
dc.contributor.authorPesic, Vesna
dc.contributor.authorMassy, Ziad
dc.contributor.authorWagner, Carsten A.
dc.contributor.authorConsortium, Connect
dc.date.accessioned2024-05-06T11:01:41Z
dc.date.available2024-05-06T11:01:41Z
dc.date.issued2024en_US
dc.departmentFakülteler, Eczacılık Meslek Bilimleri Bölümü, Farmakoloji Ana Bilim Dalıen_US
dc.description.abstractMild cognitive impairment (MCI) is common in people with chronic kidney disease (CKD) and its prevalence increases with progressive loss of kidney function. MCI is characterized by a decline in cognitive performance greater than expected for an individual age and education level but with minimal impairment of instrumental activities of daily living. Deterioration can affect one or several cognitive domains (attention, memory, executive functions, language, and perceptual motor or social cognition). Given the increasing prevalence of kidney disease, more and more people with CKD will also develop MCI causing an enormous disease burden for these individuals, their relatives and society. However, the underlying pathomechanisms are poorly understood and current therapies mostly aim at supporting patients in their daily life. This illustrates the urgent need to elucidate the pathogenesis, and potential therapeutic targets and test novel therapies in appropriate preclinical models. Here, we will outline the necessary criteria for experimental modelling of cognitive disorders in CKD. We discuss the use of mice, rats and zebrafish as model systems and present valuable techniques through which kidney function and cognitive impairment can be assessed in this setting. Our objective is to enable researchers to overcome hurdles and accelerate preclinical research aimed at improving therapy of people with CKD and MCI.en_US
dc.identifier.citationSilva, P. H. I., Pepin, M., Figurek, A., Gutieerez-Jimenez, E., Bobot, M., Iervolino, A., Mattace-Raso, F., Hoorn, E. J., Bailey, M. A., Henaut, L., Nielsen, R., Frische, S., Trepiccione, F., Hafez, G., Altunkaynak, H. O., Endlich, N., Unwin, R., Capasso, G., Pesic, V., Massy, Z., Wagner, C. A., Consortium, C. (2024). Animal models to study cognitive impairment of chronic kidney disease. American Journal of Physiology. Renal Physiology, 326(6), F894-F916. 10.1152/ajprenal.00338.2023en_US
dc.identifier.endpageF916en_US
dc.identifier.issn1931-857X
dc.identifier.issn1522-1466
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85194112846
dc.identifier.scopusqualityQ1
dc.identifier.startpageF894en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4677
dc.identifier.volume326en_US
dc.identifier.wosWOS:001386368400003
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorHafez, Gaye
dc.language.isoen
dc.relation.ispartofAmerican Journal of Physiology. Renal Physiology.
dc.relation.isversionof10.1152/ajprenal.00338.2023en_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBehavioren_US
dc.subjectChronic kidney diseaseen_US
dc.subjectCognitive impairmenten_US
dc.subjectPreclinical modelen_US
dc.titleAnimal models to study cognitive impairment of chronic kidney disease
dc.typeReview Article

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