Thalassemia-free and graft-versus-host-free survival: Outcomes of hematopoietic stem cell transplantation for thalassemia major, Turkish experience

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dc.contributor.authorYeşilipek, M. Akif
dc.contributor.authorUygun, Vedat
dc.contributor.authorKüpesiz, Alphan
dc.contributor.authorKarasu, Gülsün
dc.contributor.authorÖztürk, Gülyüz
dc.contributor.authorErtem, Mehmet
dc.contributor.authorŞaşmaz, İlgen
dc.contributor.authorDaloğlu, Hayriye
dc.contributor.authorGüler, Elif
dc.contributor.authorHazar, Volkan
dc.contributor.authorFışgın, Tunç
dc.contributor.authorSezgin, Gülay
dc.contributor.authorKansoy, Savaş
dc.contributor.authorKuşkonmaz, Barış
dc.contributor.authorAkıncı, Burcu
dc.contributor.authorÖzbek, Namık
dc.contributor.authorÜnal-İnce, Elif
dc.contributor.authorÖztürkmen, Seda
dc.contributor.authorKüpesiz-Tayfun, Funda
dc.contributor.authorYalçın, Koray
dc.contributor.authorAnak, Sema
dc.contributor.authorBozkurt, Ceyhun
dc.contributor.authorKarakükçü, Musa
dc.contributor.authorKüpeli, Serhan
dc.contributor.authorAlbayrak, Davut
dc.contributor.authorÖniz, Haldun
dc.contributor.authorAksoylar, Serap
dc.contributor.authorVisal-Okur, Fatma
dc.contributor.authorAlbayrak, Canan
dc.contributor.authorDemir-Yenigürbüz, Fatma
dc.contributor.authorOk-Bozkaya, İkbal
dc.contributor.authorİleri, Talia
dc.contributor.authorGürsel, Orhan
dc.contributor.authorKaragün, Barbaros Şahin
dc.contributor.authorTüysüz-Kintrup, Gülen
dc.contributor.authorÇelen, Suna
dc.contributor.authorElli, Murat
dc.contributor.authorAdaklı-Aksoy, Başak
dc.contributor.authorYılmaz, Ebru
dc.contributor.authorTanyeli, Atila
dc.contributor.authorTuran-Akyol, Şule
dc.contributor.authorÖnder-Siviş, Zuhal
dc.contributor.authorÖzek, Gülcihan
dc.contributor.authorUçkan, Duygu
dc.contributor.authorKartal, İbrahim
dc.contributor.authorAtay, Didem
dc.contributor.authorArzu, Akyay
dc.contributor.authorArman-Bilir, Özlem
dc.contributor.authorÇakmaklı, Hasan Fatih
dc.contributor.authorKürekçi, Emin
dc.contributor.authorMalbora, Barış
dc.contributor.authorAkbayram, Sinan
dc.contributor.authorDemir, Hacı Ahmet
dc.contributor.authorKılıç, Suar Çakı
dc.contributor.authorGüneş, Adalet Meral
dc.contributor.authorZengin, Emine
dc.contributor.authorÖzmen, Salih
dc.contributor.authorAntmen, Ali Bülent
dc.date.accessioned2022-04-06T08:04:23Z
dc.date.available2022-04-06T08:04:23Z
dc.date.issued2022en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractWe report the national data on the outcomes of hematopoietic stem cell transplantation (HSCT) for thalassemia major (TM) patients in Turkey on behalf of the Turkish Pediatric Stem Cell Transplantation Group. We retrospectively enrolled 1469 patients with TM who underwent their first HSCT between 1988 and 2020 in 25 pediatric centers in Turkey. The median follow-up duration and transplant ages were 62 months and 7 years, respectively; 113 patients had chronic graft versus host disease (cGVHD) and the cGVHD rate was 8.3% in surviving patients. Upon the last visit, 30 patients still had cGvHD (2.2%). The 5-year overall survival (OS), thalassemia-free survival (TFS) and thalassemia-GVHD-free survival (TGFS) rates were 92.3%, 82.1%, and 80.8%, respectively. cGVHD incidence was significantly lower in the mixed chimerism (MC) group compared to the complete chimerism (CC) group (p < 0.001). In survival analysis, OS, TFS, and TGFS rates were significantly higher for transplants after 2010. TFS and TGFS rates were better for patients under 7 years and at centers that had performed over 100 thalassemia transplants. Transplants from matched unrelated donors had significantly higher TFS rates. We recommend HSCT before 7 years old in thalassemia patients who have a matched donor for improved outcomes.en_US
dc.identifier.citationYesilipek, M. A., Uygun, V., Kupesiz, A., Karasu, G., Ozturk, G., Ertem, M., ... & Antmen, A. B. (2022). Thalassemia-free and graft-versus-host-free survival: outcomes of hematopoietic stem cell transplantation for thalassemia major, Turkish experience. Bone Marrow Transplantation, 1-8.en_US
dc.identifier.endpage8en_US
dc.identifier.scopus2-s2.0-85125139401
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2314
dc.identifier.wosWOS:000761872800003
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorFışgın, Tunç
dc.institutionauthorAlbayrak, Canan
dc.institutionauthorAdaklı-Aksoy, Başak
dc.institutionauthorKartal, İbrahim
dc.language.isoen
dc.publisherBone Marrow Transplantationen_US
dc.relation.ispartofBone Marrow Transplantation
dc.relation.isversionof10.1038/s41409-022-01613-wen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleThalassemia-free and graft-versus-host-free survival: Outcomes of hematopoietic stem cell transplantation for thalassemia major, Turkish experience
dc.typeReport

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