Radiotherapy increases aMMP-8-levels and neutrophil/lymphocyte ratio rapidly in head and neck cancer patients: a pilot study

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dc.contributor.authorBrandt, Ella
dc.contributor.authorKeskin, Mutlu
dc.contributor.authorTervahartiala, Taina
dc.contributor.authorYılmaz, Mustafa
dc.contributor.authorHarmankaya, İlknur
dc.contributor.authorKaraçetin, Didem
dc.contributor.authorİpek, Turgut
dc.contributor.authorGürsoy, Ulvi Kahraman
dc.contributor.authorRautava, Jaana
dc.contributor.authorGupta, Shipra
dc.contributor.authorHagström, Jaana
dc.contributor.authorRaisanen, Ismo T.
dc.contributor.authorSorsa, Timo
dc.date.accessioned2023-05-10T10:00:00Z
dc.date.available2023-05-10T10:00:00Z
dc.date.issued2023en_US
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Ağız ve Diş Sağlığı Programıen_US
dc.description.abstractRadiotherapy for head and neck carcinoma (HNC) has both curative and palliative purposes. This study investigated mouthrinse aMMP-8 levels, molecular forms of MMP-8, blood neutrophil counts and neurophil/lymphocyte ratios before and 3 weeks after HNC radiotherapy started. Thirteen HNC patients undergoing radiotherapy were included. Mouthrinse samples (before and 3 weeks after HNC radiotherapy had started) were assayed quantitatively by aMMP-8 point-of-care-kit (PerioSafe®/ORALyzer®) and by western immunoblot. Total neutrophil counts and neutrophil/lymphocyte ratios were evaluated in the hemogram results. Three weeks after HNC radiotherapy started, significant increases in aMMP-8 levels and neutrophil/lymphocyte ratios were observed. No significant difference was found in total neutrophil counts. Elevations of the activated and fragmented MMP-8 levels after HNC radiotherapy application were observed on western immunoblot analysis. The increase in the aMMP-8 levels and neutrophil/lymphocyte ratios indicate inflammation both locally and systemically suggesting increased risk for periodontitis due to the HNC radiotherapy.en_US
dc.identifier.citationBrandt, E., Keskin, M., Tervahartiala, T., Yılmaz, M., Harmankaya, İ., Karaçetin, D., ... & Sorsa, T. (2023). Radiotherapy increases aMMP-8-levels and neutrophil/lymphocyte ratio rapidly in head and neck cancer patients: a pilot study. Cancer Control, 30.en_US
dc.identifier.issn1073-2748
dc.identifier.issn1526-2359
dc.identifier.scopus2-s2.0-85153804348
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://hdl.handle.net/20.500.12939/3487
dc.identifier.volume30en_US
dc.identifier.wosWOS:000985498100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKeskin, Mutlu
dc.institutionauthorİpek, Turgut
dc.language.isoen
dc.relation.ispartofCancer control : journal of the Moffitt Cancer Center
dc.relation.isversionof10.1177/10732748231163653en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectaMMP -8en_US
dc.subjectHead And Neck Canceren_US
dc.subjectMatrix Metalloproteinasesen_US
dc.subjectNeutrophil/Lymphocyte Ratioen_US
dc.subjectPoint Of Care Technologyen_US
dc.subjectRadiotherapyen_US
dc.titleRadiotherapy increases aMMP-8-levels and neutrophil/lymphocyte ratio rapidly in head and neck cancer patients: a pilot study
dc.typeArticle

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