Visuo-spatial learning and memory deficits in C57BL/6 mice following postnatal ethanol exposure

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dc.contributor.authorDursun, İlknur
dc.contributor.authorElibol, Birsen
dc.date.accessioned2025-08-14T15:11:53Z
dc.date.available2025-08-14T15:11:53Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri, Fizyoloji Ana Bilim Dalı
dc.descriptionCODEN : AJDAB
dc.description.abstractBackground: Postnatal alcohol exposure impairs the development of the central nervous system, including the visual system. The behavioral consequences of such exposure on visual function remain poorly understood. Objectives: In this study, we investigated the effects of postnatal ethanol exposure on visuospatial learning and memory in C57BL/6 mice. Methods: Ethanol (3.0 g/kg) was administered via intubation on postnatal days 3–20. Controls received intubation only or no intervention. Pups were assigned to alcohol-treated (A, n = 11), intubation control (IC, n = 11), or non-intubated control (C, n = 9) groups. At three months, mice underwent the Novel Object Recognition (NOR) test and a visual water task. The NOR test measured recognition memory and exploratory behavior. The visual water task assessed visual acuity using sinusoidal gratings presented on monitors. Mice were trained over 17 days to associate a grating with a hidden platform, and visual acuity thresholds were determined based on performance at varying spatial frequencies. Results: Alcohol-exposed mice showed significant deficits in recognition memory and visual acuity. No group differences in body weight were observed. However, alcohol-treated mice displayed reduced exploration of novel objects (p =.0085, R2 = 0.29) and lower visual acuity thresholds at higher spatial frequencies (p =.048, R2 = 0.24). Conclusion: These findings demonstrate that early postnatal alcohol exposure can lead to lasting impairments in visual-cognitive functions. Given their similarity to deficits seen in children with Fetal Alcohol Spectrum Disorders (FASD), our results suggest the importance of early behavioral and visual assessments in children with suspected prenatal or early postnatal alcohol exposure.
dc.description.sponsorshipFunding agency : Altınbaş University Research Council. Grant number : PB2017-BAHAR-TIP-4
dc.identifier.citationDursun, I., & Elibol, B. (2025). Visuo-spatial learning and memory deficits in C57BL/6 mice following postnatal ethanol exposure. The American Journal of Drug and Alcohol Abuse, 1-11. 10.1080/00952990.2025.2526114
dc.identifier.doi10.1080/00952990.2025.2526114
dc.identifier.issn0095-2990
dc.identifier.issn1097-9891
dc.identifier.pmid40658943
dc.identifier.scopus2-s2.0-105010866220
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5861
dc.identifier.wosWOS:001528153900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Group LLC Philadelphia
dc.relation.ispartofThe American Journal of Drug and Alcohol Abuse
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectC57BL/6 mice
dc.subjectnovel object recognition
dc.subjectPostnatal alcohol exposure
dc.subjectvisual acuity task
dc.subjectvisual discrimination task
dc.titleVisuo-spatial learning and memory deficits in C57BL/6 mice following postnatal ethanol exposure
dc.typeArticle

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