A sepsis case caused by a rare opportunistic pathogen: Bacillus pumilus

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dc.contributor.authorBorsa, Barış Ata
dc.contributor.authorAldag, Mehmet Ersoy
dc.contributor.authorTunalı, Birsen
dc.contributor.authorDinç, Uğur
dc.contributor.authorGüngördü Dalar, Zeynep
dc.contributor.authorÖzalp, Veli Cengiz
dc.date.accessioned2021-05-15T12:37:05Z
dc.date.available2021-05-15T12:37:05Z
dc.date.issued2016
dc.departmentTıp Fakültesi, Biyokimya Anabilim Dalıen_US
dc.descriptionOzalp, Veli Cengiz/0000-0002-7659-5990; GUNGORDU DALAR, Zeynep/0000-0003-2177-4235
dc.description.abstractThe high prevalence of Bacillus species in nature and the detection of these bacteria as contaminant in cultures may lead diagnostic dilemma, however they should still be considered as a pathogen particularly in case of repeated positive cultures from patients with risk factors. Bacillus pumilus is a bacteria, though rarely, been reported as the causative agent of various infections such as sepsis, endocarditis, skin infections and food poisoning in human. In this report, a sepsis case in an immunocompetent patient caused by B. pumilus was presented. A 38-year-old female patient was admitted to emergency service of our hospital with the complaints of headache, dizziness and diarrhea. She had not any risk factors except a history of heart valve replacement operation two years ago. In physical examination, she had abdominal retention, high fever and hypotension, together with the high levels of sedimentation rate (ESR) and C-reactive protein (CRP). The patient was hospitalized with the preliminary diagnosis of sepsis. Three sets of blood samples at two different periods were taken for the culture. All blood culture vials had a positive signal at the second day of incubation in BD BACTEC (TM) 9050 system, therefore subcultures were performed in sheep blood agar, chocolate agar and MacConkey agar, and incubated in aerobic and anaerobic conditions. Beta-haemolytic, gray-colored large colonies were isolated from anaerobic culture at the end of 18-24 hours incubation, and Gram staining from colonies showed gram-positive rods. The isolate was identified as B. pumilus with 99% accuracy rate by using BD Phoenix (TM) 100 identification system. This result was also confirmed by MALDI-TOF based VITEK (R) MS system and 16S rRNA sequencing by Illumina MiSeq (R) platform. Antibiotic susceptibility test performed by BD Phoenix (TM) 100 system and the isolate was found to be resistant against penicillin, while it was susceptible to vancomycin, erythromycin, clindamycin, levofloxacin, and trimethoprim-sulfamethoxazole. Initial treatment of patient was started with intravenous ceftriaxone and metronidazole empirically. Hypotension and fever returned to normal levels at the second and third days of the treatment, respectively. Metronidazole treatment was stopped at seventh day, and treatment was completed to 14 day with ceftriaxone alone. At the end of the treatment course, general condition of the patient was completely good, ESR and CRP were also decreased to normal levels. In conclusion, although most of the reported bloodstream infections that are caused by B. pumilus are intravascular catheter-related, artificial heart valves should also be considered as a risk factor even though vegetation was not detected in our patient.en_US
dc.identifier.doi10.5578/mb.27575
dc.identifier.endpage470en_US
dc.identifier.issn0374-9096
dc.identifier.issue3en_US
dc.identifier.pmid27525402
dc.identifier.scopus2-s2.0-84994034502
dc.identifier.scopusqualityQ3
dc.identifier.startpage466en_US
dc.identifier.urihttps://doi.org/10.5578/mb.27575
dc.identifier.urihttps://hdl.handle.net/20.500.12939/472
dc.identifier.volume50en_US
dc.identifier.wosWOS:000381942800012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzalp, Veli Cengiz
dc.institutionauthorBorsa, Barış Ata
dc.language.isotr
dc.publisherAnkara Microbiology Socen_US
dc.relation.ispartofMikrobiyoloji Bulteni
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBacillus Pumilusen_US
dc.subjectSepsisen_US
dc.subjectHeart Valve Replacementen_US
dc.titleA sepsis case caused by a rare opportunistic pathogen: Bacillus pumilus
dc.typeArticle

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