aMMP-8 oral Fluid PoC test in relation to oral and systemic diseases

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dc.contributor.authorSorsa, Timo
dc.contributor.authorNwhator, Solomon Olusegun
dc.contributor.authorSakellari, Dimitra
dc.contributor.authorGrigoriadis, Andreas
dc.contributor.authorUmeizudike, Kehinde Adesola
dc.contributor.authorBrandt, Ella
dc.contributor.authorKeskin, Mutlu
dc.contributor.authorTervahartiala, Taina
dc.contributor.authorParnanen, Pirjo
dc.contributor.authorGupta, Shipra
dc.contributor.authorMohindra, Ritin
dc.contributor.authorBostancı, Nagihan
dc.contributor.authorBuduneli, Nurcan
dc.contributor.authorRaisanen, Ismo Tapani
dc.date.accessioned2022-07-05T12:31:51Z
dc.date.available2022-07-05T12:31:51Z
dc.date.issued2022en_US
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Ağız ve Diş Sağlığı Programıen_US
dc.description.abstractThe manuscript uses the previously published literature and highlights the benefits of active-matrix metalloproteinase (aMMP)-8 chairside/point-of-care (PoC) diagnostic tools as adjunctive measures in oral and systemic diseases. Previous studies suggest that as a biomarker, aMMP-8 is more precise than total MMP-8, MMP-9, MMP-2, MMP-3, MMP-13, MMP-7, MMP-1, calprotectin, myeloperoxidase (MPO), human neutrophil elastase (HNE), tissue inhibitor of matrix metalloproteinase (TIMP)-1, and bleeding of probing (BOP). Therefore, aMMP-8 could be implemented as the needed key biomarker for the new disease classification for both periodontitis and peri-implantitis. With a sensitivity to the tune of 75-85% and specificity in the range of 80-90%, lateral flow aMMP-8 PoC testing is comparable to catalytic protease activity assays for aMMP-8. The test can be further applied to estimate the glycemic status of an individual, to ascertain whether a person is at risk for COVID-19, in managing the oral side effects of radiotherapy carried in head and neck cancers, and in selected cases pertaining to reproductive health. In the future, aMMP-8 could find application as a potential systemic biomarker in diseases affecting the cardiovascular system, cancers, bacteremia, sepsis, diabetes, obesity, meningitis, as well as pancreatitis. The aMMP-8 PoCT is the first practical test in the emerging new dental clinical field, that is, oral clinical chemistry representing oral medicine, clinical chemistry, peri-implantology, and periodontology.en_US
dc.identifier.citationSorsa, T., Nwhator, S. O., Sakellari, D., Grigoriadis, A., Umeizudike, K. A., Brandt, E., Keskin, M., Tervahartiala, T., Parnanen, P., Gupta, S., Mohidra, R., Bostancı, N., Buduneli, N., Räisänen, I. T. (2022). aMMP-8 oral fluid PoC test in relation to oral and systemic diseases. Frontiers in Oral Health, 3.en_US
dc.identifier.scopus2-s2.0-85147181024
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2620
dc.identifier.volume3en_US
dc.identifier.wosWOS:000995166500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKeskin, Mutlu
dc.language.isoen
dc.relation.ispartofFront Oral Health
dc.relation.isversionof10.3389/froh.2022.897115en_US
dc.relation.publicationcategoryKonferans Öğesi - Ulusal - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAmmp-8en_US
dc.subjectPoint-Of-Care (Poc)en_US
dc.subjectBiomarkeren_US
dc.subjectPeriodontitisen_US
dc.subjectPeri-Implantitisen_US
dc.subjectSystemic Diseasesen_US
dc.titleaMMP-8 oral Fluid PoC test in relation to oral and systemic diseases
dc.typeArticle

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