Antimicrobial peptides: Could cecropin A and nisin be new promising agents for the treatment of anaerobic infections

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dc.contributor.authorKurt, Zeynep
dc.contributor.authorDemirci, Mehmet
dc.contributor.authorArı, Şule
dc.contributor.authorTokuç, Edip
dc.contributor.authorKılınçaslan, Ayşe Ceylan
dc.contributor.authorZiyad, Muhuyedin Abdirahman
dc.contributor.authorKocazeybek, Bekir Sami
dc.contributor.authorToman, Hrisi Bahar
dc.date.accessioned2025-01-29T10:34:38Z
dc.date.available2025-01-29T10:34:38Z
dc.date.issued2024en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri, Tıbbi Mikrobiyoloji Ana Bilim Dalıen_US
dc.description.abstractAntimicrobial peptides (AMPs) may mitigate the danger of increasing antimicrobial resistance. We aimed to determine the activities of catestatin, temporin A, nisin and cecropin A against Bacteroides fragilis ATCC 25285, Prevotella melaninogenica ATCC 25845, Cutibacterium acnes ATCC 6919, Peptostreptococcus anaerobius ATCC 27337 and Peptostreptococcus stomatis DSM 17678. strains. The susceptibility of all anaerobic bacteria was determined by Kirby-Bauer disc diffusion method, agar dilution and broth microdilution method, recommended by CLSI. By broth microdilution the MIC of temporin A for P. anaerobius was 500µg/mL, and MBC >500µg/mL. The MIC of nisin for P. melaninogenica was 200µg/mL, with a MBC of 400µg/mL, for C. acnes, P. anaerobius, and P. stomatis, MIC were 40mg/mL. The MIC of cecropin A for B. fragilis was 50µg/mL, MBC was 500µg/mL. For C. acnes, the MIC was 4µg/mL, MBC was 8µg/mL. The MIC for P. melaninogenica, P. anaerobius and P. stomatis were 8µg/mL, with corresponding MBC values of 16, 32 and 50µg/mL, respectively. Conversely, catestatin proved ineffective against all strains. In conclusion, our study, demonstrated that cecropin A and nisin showed promising results against anaerobic standard strains. We believe thatfurther research conducted to explore those AMPs could hold promise as a treatment option for anaerobic bacterial infections.en_US
dc.identifier.citationKurt, Z., Demirci, M., Arı, S., Tokuç, E., Kılıncaslan, A. C., Ziyad, M. A., Kocazeybek, B. S., Tokman, H. B. (2024). Antimicrobial peptides: Could cecropin A and nisin be new promising agents for the treatment of anaerobic infections. Pakistan Journal of Pharmaceutical Sciences, 37(6), 1331-1341.en_US
dc.identifier.endpage1341en_US
dc.identifier.issn1011-601X
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85214869509
dc.identifier.scopusqualityQ3
dc.identifier.startpage1331en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5156
dc.identifier.volume37en_US
dc.identifier.wosWOS:001396523500010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKurt, Zeynep
dc.language.isoen
dc.relation.ispartofPakistan Journal of Pharmaceutical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntimicrobial peptides (AMPs)en_US
dc.subjectCecropin Aen_US
dc.subjectNisinen_US
dc.subjectAnaerobic infectionsen_US
dc.titleAntimicrobial peptides: Could cecropin A and nisin be new promising agents for the treatment of anaerobic infections
dc.typeArticle

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