Hydrogels from Protein-Polymer Conjugates: A Pathway to Next-Generation Biomaterials

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dc.contributor.authorAlayoubi, Oubadah
dc.contributor.authorPoyraz, Yağmur
dc.contributor.authorHassan, Gana
dc.contributor.authorGül, Sümeyye Berfin
dc.contributor.authorÇalhan, Nergiz
dc.contributor.authorŞahin, Naz Mina Mert
dc.contributor.authorGautam, Megham
dc.contributor.authorKutlu, Aylin
dc.contributor.authorÖzuğur Uysal, Bengü
dc.contributor.authorAkten, Ebru Demet
dc.contributor.authorPekcan, Önder
dc.date.accessioned2025-05-12T10:21:05Z
dc.date.available2025-05-12T10:21:05Z
dc.date.issued2025
dc.departmentFakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Temel Bilimler Bölümü
dc.description.abstractHybrid hydrogels from protein–polymer conjugates are biomaterials formed via the chemical bonding of a protein molecule with a polymer molecule. Protein–polymer conjugates offer a variety of biological properties by combining the mechanical strength of polymers and the bioactive functionality of proteins. These properties allow these conjugates to be used as biocompatible components in biomedical applications. Protein–polymer conjugation is a vital bioengineering strategy in many fields, such as drug delivery, tissue engineering, and cancer therapy. Protein–polymer conjugations aim to create materials with new and unique properties by combining the properties of different molecular components. There are various ways of creating protein–polymer conjugates. PEGylation is one of the most common conjugation techniques where a protein is conjugated with Polyethylene Glycol. However, some limitations of PEGylation (like polydispersity and low biodegradability) have prompted researchers to devise novel synthesis techniques like PEGylation, where synthetic polypeptides are used as the polymer component. This review will illustrate the properties of protein–polymer conjugates, their synthesis methods, and their various biomedical applications.
dc.identifier.citationAlayoubi, O., Poyraz, Y., Hassan, G., Gül, S. B., Çalhan, N., Şahin, N. M. M., ... & Pekcan, Ö. (2025). Hydrogels from protein–polymer conjugates: A pathway to next-generation biomaterials. Gels, 11(2), 96.
dc.identifier.doi10.3390/gels11020096
dc.identifier.issn2310-2861
dc.identifier.issue2
dc.identifier.pmid39996639
dc.identifier.scopus2-s2.0-85219170336
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5742
dc.identifier.volume11
dc.identifier.wosWOS:001431888900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzuğur Uysal, Bengü
dc.language.isoen
dc.relation.ispartofGels
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecthybrid hydrogels
dc.subjectPEGylation
dc.subjectprotein–polymer conjugates
dc.titleHydrogels from Protein-Polymer Conjugates: A Pathway to Next-Generation Biomaterials
dc.typeOther

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