Design of an orally disintegrating tablet formulation containing metoprolol tartrate in the context of quality by design approach

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dc.contributor.authorYeğen, Gizem
dc.contributor.authorAksu, Buket
dc.contributor.authorCevher, Erdal
dc.date.accessioned2022-01-21T06:08:22Z
dc.date.available2022-01-21T06:08:22Z
dc.date.issued2021en_US
dc.departmentFakülteler, Eczacılık Fakültesien_US
dc.description.abstractOrally Disintegrating Tablets (ODTs) are solid dosage forms that rapidly disintegrate or dissolve to release the drug upon contact with saliva in the mouth. As these tablets require special attention during formulation design, it is necessary to use advanced control and formulation design techniques to increase the quality. Quality by Design (QbD) was defined as an approach including better scientific understanding of critical process and product attributes, designing controls and tests based on scientific understanding limits during development stage and used to work in an environment for continuous improvement of information obtained during the product lifecycle. The aim of the study was to develop an ODT formulation containing Metoprolol tartrate with appropriate features via QbD approach with the help of artificial intelligence programs to enlight the multivariate relations between critical parameters and quality attributes of on final product and to obtain an optimum formulation. Physical and chemical tests were conducted on tablets prepared by direct compression according to the designated formulation and process variables. Then, experimental data was evaluated with modeling programs use artificial intelligence technique, FormRules V3.32 to understand the relationship between independent input variables and the critical quality attributes; later with INForm V5.1 for optimization. The optimized formula was prepared and according to test results tablets shows compliance with the pharmacopoeia limits. The adoption of QbD approach and usage of artificial intelligence programs has increased the efficiency of the formulation development process with better understanding of the product and process.en_US
dc.identifier.citationYeğen, G., Aksu, B., Cevher, E. (2021). Design of an orally disintegrating tablet formulation containing metoprolol tartrate in the context of quality by design approach. Journal of Research in Pharmacy, 728-737.en_US
dc.identifier.endpage737en_US
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85115766158
dc.identifier.scopusqualityQ3
dc.identifier.startpage728en_US
dc.identifier.trdizinid489767
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2217
dc.identifier.volume25en_US
dc.identifier.wosWOS:000701782800020
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorAksu, Buket
dc.language.isoen
dc.publisherMarmara University Pressen_US
dc.relation.ispartofJournal of Research in Pharmacy
dc.relation.isversionof10.29228/jrp.63en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectArtificial Intelligenceen_US
dc.subjectOrally Disintegrating Tableten_US
dc.subjectQuality By Designen_US
dc.subjectMetoprolol Tartrateen_US
dc.titleDesign of an orally disintegrating tablet formulation containing metoprolol tartrate in the context of quality by design approach
dc.typeArticle

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