COVID-19 disease in children and adolescents following allogeneic hematopoietic stem cell transplantation: A report from the Turkish pediatric bone marrow transplantation study group

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dc.contributor.authorBozkurt, Ceyhun
dc.contributor.authorHazar, Volkan
dc.contributor.authorMalbora, Barış
dc.contributor.authorKüpesiz, Alphan
dc.contributor.authorAygüneş, Utku
dc.contributor.authorFışgın, Tunç
dc.contributor.authorKarakükçü, Musa
dc.contributor.authorKuşkonmaz, Barış
dc.contributor.authorKılıç, Suar Çakı
dc.contributor.authorBayırlı, Derya
dc.contributor.authorBilir, Özlem Arman
dc.contributor.authorYalçın, Koray
dc.contributor.authorGözmen, Salih
dc.contributor.authorUygun, Vedat
dc.contributor.authorElli, Murat
dc.contributor.authorSarbay, Hakan
dc.contributor.authorKüpesiz, Funda Tayfun
dc.contributor.authorŞaşmaz, Hatice İlgen
dc.contributor.authorAksoy, Başak Adaklı
dc.contributor.authorYılmaz, Ebru
dc.contributor.authorOkur, Fatma Visal
dc.contributor.authorTekkeşin, Funda
dc.contributor.authorYenigürbüz, Fatma Demir
dc.contributor.authorÖzek, Gülcihan
dc.contributor.authorAtay, Abdullah Avni
dc.contributor.authorBozkaya, İkbal Ok
dc.contributor.authorÇelen, Suna
dc.contributor.authorÖztürkmen, Seda
dc.contributor.authorGüneş, Adalet Meral
dc.contributor.authorGürsel, Orhan
dc.contributor.authorGüler, Elif
dc.contributor.authorÖzcan, Alper
dc.contributor.authorÇetinkaya, Duygu Uçkan
dc.contributor.authorAydoğdu, Selime
dc.contributor.authorÖzbek, Namık Yaşar
dc.contributor.authorKarasu, Gülsün
dc.contributor.authorSezgin, Gülay
dc.contributor.authorDoğru, Ömer
dc.contributor.authorAlbayrak, Davut
dc.contributor.authorÖztürk, Gülyüz
dc.contributor.authorAksoylar, Serap
dc.contributor.authorDaloğlu, Hayriye
dc.contributor.authorAl, Işık Odaman
dc.contributor.authorEvim, Melike Sezgin
dc.contributor.authorAkbayram, Sinan
dc.contributor.authorÖncül, Yurday
dc.contributor.authorZengin, Emine
dc.contributor.authorAlbayrak, Canan
dc.contributor.authorTimur, Çetin
dc.contributor.authorKar, Yeter Düzenli
dc.contributor.authorÇakmaklı, Hasan Fatih
dc.contributor.authorTüfekçi, Özlem
dc.contributor.authorTöret, Ersin
dc.contributor.authorAntmen, Bülent
dc.date.accessioned2024-05-06T12:53:12Z
dc.date.available2024-05-06T12:53:12Z
dc.date.issued2024en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractBackground: Data on the risk factors and outcomes for pediatric patients with SARS-CoV-2 infection (COVID-19) following hematopoietic stem cell transplantation (HSCT) are limited. Objectives: The study aimed to analyze the clinical signs, risk factors, and outcomes for ICU admission and mortality in a large pediatric cohort who underwent allogeneic HSCT prior to COVID-19 infection. Method: In this nationwide study, we retrospectively reviewed the data of 184 pediatric HSCT recipients who had COVID-19 between March 2020 and August 2022. Results: The median time from HSCT to COVID-19 infection was 209.0 days (IQR, 111.7-340.8; range, 0-3845 days). The most common clinical manifestation was fever (58.7%). While most patients (78.8%) had asymptomatic/mild disease, the disease severity was moderate in 9.2% and severe and critical in 4.4% and 7.6%, respectively. The overall mortality was 10.9% (n: 20). Deaths were attributable to COVID-19 in nine (4.9%) patients. Multivariate analysis revealed that lower respiratory tract disease (LRTD) (OR, 23.20, p: .001) and lymphopenia at diagnosis (OR, 5.21, p: .006) were risk factors for ICU admission and that HSCT from a mismatched donor (OR, 54.04, p: .028), multisystem inflammatory syndrome in children (MIS-C) (OR, 31.07, p: .003), and LRTD (OR, 10.11, p: .035) were associated with a higher risk for COVID-19-related mortality. Conclusion: While COVID-19 is mostly asymptomatic or mild in pediatric transplant recipients, it can cause ICU admission in those with LRTD or lymphopenia at diagnosis and may be more fatal in those who are transplanted from a mismatched donor and those who develop MIS-C or LRTD.en_US
dc.identifier.citationBozkurt, C., Hazar, V., Malbora, B., Küpesiz, A., Aygüneş, U., Fışgın, T., Karakükçü, M., Kuşkonmaz, B., Kılıç, S. Ç., Bayırlı, D., Bilir, Ö. A., Yalçın, K., Gözmen, S., Uygun, V., Elli, M., Sarbay, H., Küpesiz, F. T., Şaşmaz, H. İ., Aksoy, B. A., Yılmaz, E., Okur, F. V:, Tekkeşin, F., Yenigürbüz, F. D., Özek, G., Atay, A. A., Bozkaya, İ. O., Çelen, S., Öztürkmen, S., Güneş, A. M., Gürsel, A. M., Gürsel, O., Güler, E., Özcan, A., Çetinkaya, D. U., Aydoğdu, S., Özbek, N. Y., Karasu, G., Sezgin, G., Doğru, Ö., Albayrak, D., Öztürk, G., Aksoylar, S., Daloğlu, H., Al I. O., Evim, M. S., Akbayram, S., Öncül, Y., Zengin, E., Albayrak, C., Timur, Ç., Kar, Y. D., Çakmaklı, H. F., Tüfekçi, Ö., Töret, E., Antmen, B. (2024). COVID-19 disease in children and adolescents following allogeneic hematopoietic stem cell transplantation: A report from the Turkish pediatric bone marrow transplantation study group. Pediatric Transplantation, 28(3). 10.1111/petr.14758en_US
dc.identifier.issn1397-3142
dc.identifier.issn1399-3046
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85191193300
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4682
dc.identifier.volume28en_US
dc.identifier.wosWOS:001207499700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorFışgın, Tunç
dc.institutionauthorAksoy, Başak Adaklı
dc.language.isoen
dc.relation.ispartofPediatric Transplantation
dc.relation.isversionof10.1111/petr.14758en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCOVID‐19en_US
dc.subjectAdolescentsen_US
dc.subjectChildrenen_US
dc.subjectHematopoietic stem cell transplantationen_US
dc.titleCOVID-19 disease in children and adolescents following allogeneic hematopoietic stem cell transplantation: A report from the Turkish pediatric bone marrow transplantation study group
dc.typeArticle

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