Relationship between serum vitamin D levels semen parameters and sperm DNA damage in men with unexplained infertility

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dc.contributor.authorGungor, K.
dc.contributor.authorGungor, N. D.
dc.contributor.authorBasar, M. M.
dc.contributor.authorCengiz, F.
dc.contributor.authorErsahin, S. S.
dc.contributor.authorCil, K.
dc.date.accessioned2025-02-06T17:58:27Z
dc.date.available2025-02-06T17:58:27Z
dc.date.issued2022
dc.departmentAltınbaş Üniversitesien_US
dc.description.abstractOBJECTIVE: The aim of the study was to investigate the relationship between serum level of vitamin D, semen analysis parameters and sperm DNA damage in men with unexplained subfertility. PATIENTS AND METHODS: Fifty-eight men diagnosed with unexplained infertility and 50 age and BMI matched fertile men were included in the study. A participant whose semen parameter is normal but pregnancy is not achieved was accepted as unexplained male infertility. Blood samples were taken from all participants following three-day abstinence for measurement of vitamin D. Sperm DNA damage was assessed by Aniline Blue staining of the collected samples. RESULTS: Compared with the fertile men, male patients with unexplained infertility had significantly lower vit D levels (27.00 ng/mL (12.6339.3 0) vs. 23.66 ng/mL (7.50-55.00), p<0.004). While the number of patients with vitamin D levels lower than 20 ng/mL was 26 (44.8%) in the infertile group, it was recorded as 5 (10.0%) in the fertile group (p<0.001). DNA damage was found in 31.50% (9.0-71.0) of the infertile men and 26.00% (11.0-54.0) of the fertile men. DNA damage was found to be significantly higher in the unexplained infertile group (p<0.002). In men with unexplained male infertility, serum vit D levels were positively correlated with total sperm count (r = 0.527, p<0.001), total motility (r = 0.527, p<0.001) and sperm morphology (r = 0.416, p = 0.001). There was a negative and significant correlation between vit D levels and sperm DNA damage (r =-0.605, p<0.001). In the logistic regression analysis, serum vit D > 20 ng/mL led to an improvement in fertility outcome. CONCLUSIONS: Men with unexplained infertility exhibit decreased serum vit D levels and increased sperm DNA damage.en_US
dc.identifier.endpage505en_US
dc.identifier.issn1128-3602
dc.identifier.issue2en_US
dc.identifier.pmid35113426
dc.identifier.scopus2-s2.0-85123973867
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage499en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5268
dc.identifier.volume26en_US
dc.identifier.wosWOS:000753911000020
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250206
dc.subjectUnexplained male infertilityen_US
dc.subjectSemenen_US
dc.subjectSperm DNA damageen_US
dc.subjectVit Den_US
dc.titleRelationship between serum vitamin D levels semen parameters and sperm DNA damage in men with unexplained infertilityen_US
dc.typeArticleen_US

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