Albuminuria as a risk factor for mild cognitive impairment and dementia—what is the evidence?

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dc.contributor.authorBikbov, Boris
dc.contributor.authorSoler, Maria Jose
dc.contributor.authorPesic, Vesna
dc.contributor.authorCapasso, Giovambattista
dc.contributor.authorUnwin, Robert
dc.contributor.authorEndres, Matthias
dc.contributor.authorRemuzzi, Giuseppe
dc.contributor.authorPerico, Norberto
dc.contributor.authorGansevoort, Ron
dc.contributor.authorMattace-Raso, Francesco
dc.contributor.authorBruchfeld, Annette
dc.contributor.authorFigurek, Andreja
dc.contributor.author(Cognitive Decline in Nephro-Neurology European Cooperative Target
dc.contributor.authorHafez, Gaye
dc.date.accessioned2022-03-03T07:23:48Z
dc.date.available2022-03-03T07:23:48Z
dc.date.issued2021en_US
dc.departmentFakülteler, Eczacılık Meslek Bilimleri Bölümü, Farmakoloji Ana Bilim Dalıen_US
dc.description.abstractKidney dysfunction can profoundly influence many organ systems, and recent evidence suggests a potential role for increased albuminuria in the development of mild cognitive impairment (MCI) or dementia. Epidemiological studies conducted in different populations have demonstrated that the presence of increased albuminuria is associated with a higher relative risk of MCI or dementia both in cross-sectional analyses and in studies with long-term follow-up. The underlying pathophysiological mechanisms of albuminuria’s effect are as yet insufficiently studied, with several important knowledge gaps still present in a complex relationship with other MCI and dementia risk factors. Both the kidney and the brain have microvascular similarities that make them sensitive to endothelial dysfunction involving different mechanisms, including oxidative stress and inflammation. The exact substrate of MCI and dementia is still under investigation, however available experimental data indicate that elevated albuminuria and low glomerular filtration rate are associated with significant neuroanatomical declines in hippocampal function and grey matter volume. Thus, albuminuria may be critical in the development of cognitive impairment and its progression to dementia. In this review, we summarize the available evidence on albuminuria’s link to MCI and dementia, point to existing gaps in our knowledge and suggest actions to overcome them. The major question of whether interventions that target increased albuminuria could prevent cognitive decline remains unanswered. Our recommendations for future research are aimed at helping to plan clinical trials and to solve the complex conundrum outlined in this review, with the ultimate goal of improving the lives of patients with chronic kidney disease.en_US
dc.identifier.citationBikbov, B., Soler, M. J., Pešić, V., Capasso, G., Unwin, R., Endres, M., ... & Hafez, G. (2022). Albuminuria as a risk factor for mild cognitive impairment and dementia—what is the evidence?. Nephrology Dialysis Transplantation, 37(2), 55-62.en_US
dc.identifier.endpage62en_US
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85123025113
dc.identifier.scopusqualityN/A
dc.identifier.startpage55en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2257
dc.identifier.volume37en_US
dc.identifier.wosWOS:000740945100007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorHafez, Gaye
dc.language.isoen
dc.publisherNephrol Dial Transplanten_US
dc.relation.ispartofNephrol Dial Transplant
dc.relation.isversionof10.1093/ndt/gfab261en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlbuminuriaen_US
dc.subjectChronic Kidney Diseaseen_US
dc.subjectDementiaen_US
dc.subjectGlomerular Filtration Rateen_US
dc.subjectMild Cognitive İmpairmenten_US
dc.titleAlbuminuria as a risk factor for mild cognitive impairment and dementia—what is the evidence?
dc.typeArticle

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