Chemistry and biological activities of tanacetum chiliophyllum var. oligocephalum extracts

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dc.contributor.authorPolatoğlu, Kaan
dc.contributor.authorKarakoç, Ömer Cem
dc.contributor.authorDemirci, Fatih
dc.contributor.authorGökçe, Ayhan
dc.contributor.authorGören, Nezhun
dc.date.accessioned2021-05-15T12:40:56Z
dc.date.available2021-05-15T12:40:56Z
dc.date.issued2013
dc.departmentEczacılık Fakültesien_US
dc.descriptionDemirci, Fatih/0000-0003-1497-3017; Gokce, Ayhan/0000-0002-5617-1349; Polatoglu, Kaan/0000-0001-5493-2995
dc.description.abstractTanacetum chiliophyllum (Fisch. & Mey.) var. oligocephalum (D.C.) Sosn. collected in Turkey was subjected to phytochemical and biological evaluations in this study. Pure compounds were obtained from ethyl acetate extracts of the stems of the plant material. Structures of isolated compounds were determined using spectral methods. Seven known flavones, i.e., 5-hydroxy-3',4',6,7-tetramethoxyflavone, eupatilin (6-hydroxyluteolin-6,3',4'-trimethylether), cirsimaritin (scuttellarin-6,7-dimethylether), cirsilineol, 5 hydroxy-3',4',7-trimethoxy flavone, desmethoxy-centaureidin, and jaceosidin and one known triterpene, taraxasterol acetate, were identified from the ethyl acetate extracts. The first seven compounds, as well as the ethyl acetate and methanol extracts, were also investigated for their insecticidal, antimicrobial, and 1,1-diphenyl-2-picrylhydrazil radical (DPPH)-scavenging activities. The insecticidal contact toxicity of the extracts were evaluated on Sitophilus granarius. The ethyl acetate (81.8%) and methanol (88.4%) extracts of T. chiliophyllum var. oligocephalum showed high toxicity against this pest. Most promising antimicrobial activity was observed for ethyl acetate extracts of the stems against Bacillus cereus. This extract showed the same inhibition concentration (125 mu L/mg) with the positive control chloramphenicol. The ethyl acetate (91.9%) and methanol (93%) extracts of the stems showed significant DPPH-scavenging activity compared with the positive controls a-tocopherol (94.5%) and butylated hydroxytoluene (92.9%) at 10 mg/mL concentration. Among the isolated compounds, the highest DPPH-scavenging activity was observed for jaceosidin at 1 mg/mL concentration (81.5%).en_US
dc.description.sponsorshipScientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TUBITAK- TBAG 104T306]; State Planning Organization [27-DPT-01-07-01]; infrastructure of Anadolu University Research FundingAnadolu University [BAP-060301]en_US
dc.description.sponsorshipThis research was supported by The Scientific and Technological Research Council of Turkey (TUBITAK- TBAG 104T306) and State Planning Organization (Project No. 27-DPT-01-07-01).Also, the infrastructure of Anadolu University Research Funding (Project No. BAP-060301) was used. We are grateful to Gamze cayirdere, who assisted the antimicrobial evaluations, and to Ahmet Ceyhan Goren for acquiring mass spectra.en_US
dc.identifier.doi10.5740/jaoacint.SGEPolatoglu
dc.identifier.endpage1227en_US
dc.identifier.issn1060-3271
dc.identifier.issn1944-7922
dc.identifier.issue6en_US
dc.identifier.pmid24645497
dc.identifier.scopus2-s2.0-84893755234
dc.identifier.scopusqualityQ2
dc.identifier.startpage1222en_US
dc.identifier.urihttps://doi.org/10.5740/jaoacint.SGEPolatoglu
dc.identifier.urihttps://hdl.handle.net/20.500.12939/712
dc.identifier.volume96en_US
dc.identifier.wosWOS:000328926300008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorPolatoğlu, Kaan
dc.language.isoen
dc.publisherAoac Inten_US
dc.relation.ispartofJournal of Aoac International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPlant Materialen_US
dc.titleChemistry and biological activities of tanacetum chiliophyllum var. oligocephalum extracts
dc.typeArticle

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