Extracorporeal photopheresis did not prevent the development of an autoimmune disease: Myasthenia gravis

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dc.contributor.authorUygun, Vedat
dc.contributor.authorDaloğlu, Hayriye
dc.contributor.authorÖztürkmen, Seda Irmak
dc.contributor.authorDöşemeci, Levent
dc.contributor.authorKarasu, Gülsün
dc.contributor.authorHazar, Volkan
dc.contributor.authorYeşilipek, Akif
dc.date.accessioned2021-05-15T12:36:55Z
dc.date.available2021-05-15T12:36:55Z
dc.date.issued2016
dc.departmentTıp Fakültesien_US
dc.description.abstractBACKGROUNDMyasthenia gravis (MG) is a neuromuscular disorder characterized by an autoimmune defect in the neuromuscular junction. In most patients, the autoimmune attack is mediated by antibodies against the acetylcholine receptor (AChR) on the postsynaptic membrane. Deficient immunoregulation, including regulatory T cells, is consistently observed. Extracorporeal photopheresis (ECP) leads to the induction of regulatory T cells that mediate immunologic tolerance in autoimmune diseases; however, the data regarding MG are very limited. CASE REPORTHere, we report a patient who, during ongoing ECP therapy for his severe, refractory, chronic graft-versus-host disease (cGVHD), developed MG, although he responded very well to ECP, as indicated by the lowering of his chronic cGVHD severity grade to moderate. RESULTSDespite receiving ECP, our patient developed MG, which was resistant to treatment and required intensive care unit support. CONCLUSIONSClose surveillance is required when ECP is planned as one of the treatment alternatives in myasthenia gravis that develop in cGVHD.en_US
dc.identifier.doi10.1111/trf.13821
dc.identifier.endpage3085en_US
dc.identifier.issn0041-1132
dc.identifier.issn1537-2995
dc.identifier.issue12en_US
dc.identifier.pmid27612294
dc.identifier.scopus2-s2.0-84992669624
dc.identifier.scopusqualityQ2
dc.identifier.startpage3081en_US
dc.identifier.urihttps://doi.org/10.1111/trf.13821
dc.identifier.urihttps://hdl.handle.net/20.500.12939/437
dc.identifier.volume56en_US
dc.identifier.wosWOS:000390578300026
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDöşemeci, Levent
dc.language.isoen
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofTransfusion
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMedicineen_US
dc.subjectMyasthenia Gravisen_US
dc.subjectAutoimmuneen_US
dc.titleExtracorporeal photopheresis did not prevent the development of an autoimmune disease: Myasthenia gravis
dc.typeArticle

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