Impact of empagliflozin on left atrial mechanical and conduction functions in patients with type 2 diabetes mellitus

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dc.contributor.authorAslan, Muzaffer
dc.contributor.authorOkşen, Doğaç
dc.contributor.authorKaynak, Çağdaş
dc.contributor.authorÖzüdoğru, Osman
dc.date.accessioned2022-11-13T07:39:49Z
dc.date.available2022-11-13T07:39:49Z
dc.date.issued2022en_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalıen_US
dc.description.abstractObjective: Empagliflozin, an oral anti-diabetic drug that inhibits the sodium-dependent glucose co-transporter 2 (SGLT2), has pleiotropic effects on the myocardium. The aim of the study is to investigate the effect of empagliflozin on atrial electromechanical delay (AEMD) and the left atrial (LA) mechanical functions in patients with type 2 diabetes mellitus (DM). Method: In total 62 patients (40.3% female, mean age 50.5 ± 8.6 years old) with type 2 DM were enrolled to the study. Participants were used a SGLT2 inhibitor (empagliflozin 10-25 mg/daily) for 6 months. Patients were examined initially and after 6 months with echocardiography. LA volume was recorded, atrial conduction times were measured using tissue Doppler imaging (TDI). Results: No significant change was observed in LA volumes (maximal, minimal, and presystolic), total emptying and passive emptying volume at the end of 6 months; however, there was a significant decrease in active emptying volume (8.3 ± 2.9 ml/m2 vs. 7.9 ± 2.9 ml/m2 , p = 0.04). The posteroanterior lateral, septal, and tricuspid conduction times significantly decreased after the empagliflozin treatment. The decrease in right inter-AEMD was statistically significant (13.25 ± 10.21 ms vs. 10.85 ± 9.14 ms, p = 0.011). The changes in inter-AEMD were found to be correlated with the changes in LA active emptying volume (r = 0.408). Conclusion: Empagliflozin may enhance the structure and electrical conductions of the atrium and may prevent DM patients from DM-2-related functional disorder and arrhythmia.en_US
dc.identifier.citationAslan, M., Okşen, D., Kaynak, C., Özüdoğru, O. (2022). Impact of empagliflozin on left atrial mechanical and conduction functions in patients with type 2 diabetes mellitus. Journal of Clinical Ultrasound, 51(3), 398-404.en_US
dc.identifier.endpage404en_US
dc.identifier.issn1097-0096
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85141390154
dc.identifier.scopusqualityQ3
dc.identifier.startpage398en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/3001
dc.identifier.volume51en_US
dc.identifier.wosWOS:000875690000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorOkşen, Doğaç
dc.language.isoen
dc.relation.ispartofJournal of Clinical Ultrasound
dc.relation.isversionof10.1002/jcu.23384en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtrial Electromechanical Delayen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectEmpagliflozinen_US
dc.subjectTissue Doppler Echocardiographyen_US
dc.titleImpact of empagliflozin on left atrial mechanical and conduction functions in patients with type 2 diabetes mellitus
dc.typeArticle

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