Screening of antimicrobial, antibiofilm, and cytotoxic activities of some medicinal plants from Balıkesir province, Türkiye: potential effects of allium paniculatum flower

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dc.authorid0000-0001-9889-9250en_US
dc.contributor.authorOyardı, Özlem
dc.contributor.authorHacıoğlu, Mayram
dc.contributor.authorÖzdemir, Ebru
dc.contributor.authorErbay, Meryem Şeyda
dc.contributor.authorKültür, Şükran
dc.contributor.authorGüzel, Çağla Bozkurt
dc.date.accessioned2024-07-19T06:14:49Z
dc.date.available2024-07-19T06:14:49Z
dc.date.issued2024en_US
dc.departmentFakülteler, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Botanik Ana Bilim Dalıen_US
dc.description.abstractObjectives: Plant extracts are important natural resources that may have antimicrobial and antibiofilm effects against pathogens. This study was conducted to investigate the in vitro antimicrobial activities of methanol extracts of some medicinal plants (Achillea nobilis subspecies neilreichii (A. Kern.) Velen., Aetheorhiza bulbosa (L.) Cass, Allium paniculatum L, Asphodelus aestivus Brot., Ballota nigra L., Cistus laurifolius L., Cistus salviifolius L., Dioscorea communis (L.) Caddick and Wilkin, Galium verum L., Hypericum triquetrifolium Turra, Paliurus spina-christi Mill., Primula vulgaris Huds. subspecies rubra (Sm.) Arcang., Ranunculus arvensis L. and Teucrium polium L.) from Balıkesir province in Türkiye. Materials and methods: Preliminary antimicrobial activity screening was conducted for all extracts. Antibiofilm activity studies were conducted on mature Candida albicans biofilms. Moreover, the cytotoxicities of A. paniculatum flower extract on A549 and Vero cell lines were determined using a colorimetric tetrazolium-based assay. Results: A. paniculatum flower, P. vulgaris root, C. laurifolius, C. salviifolius, and A. nobilis displayed good activity [minimum inhibitory concentrations (MIC): 9.75, 156, 312, 312 and 312 μg/mL, respectively] against C. albicans American Type Culture Collection 10231. Biofilm studies were conducted on these plant extracts. The methanol extract of A. paniculatum flower decreased the number of C. albicans [colony-forming unit (CFU)/mL] in mature biofilm statistically at 32 x MIC and higher concentrations (p < 0.01). A. paniculatum flower extract had a cytotoxic effect (killing more than 50% of cells) at high concentrations, and its effect on Vero cells was similar to that on A549 cells. Conclusion: This study demonstrated the importance of the methanol extract of A. paniculatum flower as a natural alternative against C. albicans infections, including biofilms.en_US
dc.identifier.citationOyardı, Ö., Hacıoğlu, M., Özdemir, E., Erbay, M. Ş., Kültür, Ş., Güzel, Ç. B. (2024). Screening of antimicrobial, antibiofilm, and cytotoxic activities of some medicinal plants from Balıkesir province, Türkiye: potential effects of allium paniculatum flower. Turkish Journal of Pharmaceutical Sciences, 21(3), 252-258. 10.4274/tjps.galenos.2023.88935en_US
dc.identifier.endpage258en_US
dc.identifier.issn2148-6247
dc.identifier.issn1304-530X
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85200694795
dc.identifier.scopusqualityQ2
dc.identifier.startpage252en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4764
dc.identifier.volume21en_US
dc.identifier.wosWOS:001279174800011
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzdemir, Ebru
dc.language.isoen
dc.relation.ispartofTurkish Journal of Pharmaceutical Sciences
dc.relation.isversionof10.4274/tjps.galenos.2023.88935en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAllium paniculatumen_US
dc.subjectAntibiofilm activityen_US
dc.subjectAntimicrobial activityen_US
dc.subjectCytotoxic activityen_US
dc.titleScreening of antimicrobial, antibiofilm, and cytotoxic activities of some medicinal plants from Balıkesir province, Türkiye: potential effects of allium paniculatum flower
dc.typeArticle

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