Intraperitoneal instillation versus wound infiltration for postoperative pain relief after cesarean delivery: A prospective, randomized, double-blind, placebo-controlled trial

dc.contributor.authorDağaşan Çetin, Gözdenur
dc.contributor.authorDostbil, Ayşenur
dc.contributor.authorAksoy, Mehmet
dc.contributor.authorKaşali, Kamber
dc.contributor.authorİnce, Ramazan
dc.contributor.authorKahramanlar, Agah Abdullah
dc.contributor.authorAtalay, Canan
dc.contributor.authorTopdağı Yılmaz, Emsal Pınar
dc.contributor.authorİnce, İlker
dc.contributor.authorÖzkal, Miraç Selcen
dc.date.accessioned2022-10-28T07:55:23Z
dc.date.available2022-10-28T07:55:23Z
dc.date.issued2022en_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractAim: To compare local anesthetic wound infiltration with intraperitoneal instillation of local anesthetic for analgesia after cesarean section under spinal anesthesia. Methods: This study was conducted on 150 pregnant women undergoing elective cesarean section under spinal anesthesia. Spinal anesthesia was performed with 7 mg isobaric bupivacaine and 15 μcg fentanyl. The patients were randomized into three groups of 50 patients each: Group local anesthetic wound infiltration (LWI): 20 ml local anesthetic solution (10 ml 0.5% bupivacaine and 10 ml 2% lidocaine mixture) was administered subcutaneous wound infiltration at the end of surgery prior to skin closure and 20 ml saline was instilled into the uterine peritoneal area before fascia closure. Group intraperitoneal local anesthetic (IPLA): 20 ml local anesthetic solution (10 ml 0.5% bupivacaine and 10 ml 2% lidocaine mixture) was instilled into the uterine peritoneal area and 20 ml saline was administered subcutaneous wound infiltration. Group Placebo: 20 ml saline was instilled into the uterine peritoneal area and 20 ml saline was administered local subcutaneous wound infiltration. Pain scores at rest and on movement, total fentanyl consumption at 24 h, maternal satisfaction, and the time to first analgesic request were recorded. Results: No statistically significant difference was observed in the postoperative pain scores at rest at 2, 12, and 24 h (p = 0.314, 0.343, and 0.735, respectively) and on movement at 12 and 24 h (p = 0.318 and 0.642, respectively) between the groups. The pain scores on movement at 2 h were significantly lower in Group IPLA compared with Group Placebo (p = 0.047). There were no significant differences between the groups in terms of total fentanyl consumption and the time to first analgesic request. Conclusion: The use of intraperitoneal instillation of bupivacaine and lidocaine reduces early the pain score on movement in women undergoing cesarean section under spinal anesthesia.en_US
dc.identifier.citationDağaşan Çetin, G., Dostbil, A., Aksoy, M., Kaşali, K., İnce, R., Kahramanlar, A. A., Atalay, C., Topdağı Yılmaz, E. P., İnce, İ., Özkal, M. S. (2022). Intraperitoneal instillation versus wound infiltration for postoperative pain relief after cesarean delivery: A prospective, randomized, double-blind, placebo-controlled trial. Journal of Obstetrics and Gynaecology Research, 49(1), 209-219.en_US
dc.identifier.endpage219en_US
dc.identifier.issn1447-0756
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85140207285
dc.identifier.scopusqualityQ2
dc.identifier.startpage209en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2986
dc.identifier.volume49en_US
dc.identifier.wosWOS:000870825100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorİnce, İlker
dc.language.isoen
dc.relation.ispartofJournal of Obstetrics and Gynaecology Research
dc.relation.isversionof10.1111/jog.15469en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCesarean Sectionen_US
dc.subjectIntraperitoneal Instillationen_US
dc.subjectSpinal Anesthesiaen_US
dc.subjectWound Infiltrationen_US
dc.titleIntraperitoneal instillation versus wound infiltration for postoperative pain relief after cesarean delivery: A prospective, randomized, double-blind, placebo-controlled trial
dc.typeArticle

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