Exploring free amino acid profiles in CCHF patients: Implications for disease progression

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dc.contributor.authorBüyüktuna, Seyit Ali
dc.contributor.authorYerlitaş, Serra İlayda
dc.contributor.authorZararsız, Gözde Ertük
dc.contributor.authorDoğan, Kübra
dc.contributor.authorKablan, Demet
dc.contributor.authorBağcı, Gökhan
dc.contributor.authorÖzer, Selda
dc.contributor.authorBaysal, Cihad
dc.contributor.authorÇakır, Yasemin
dc.contributor.authorCephe, Ahu
dc.contributor.authorKoçhan, Necla
dc.contributor.authorZararsız, Gökmen
dc.contributor.authorDoğan, Halef Okan
dc.date.accessioned2024-05-22T07:34:08Z
dc.date.available2024-05-22T07:34:08Z
dc.date.issued2024en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.description.abstractThis study investigated the intricate interplay between Crimean-Congo hemorrhagic fever virus (CCHFV) infection and alterations in amino acid metabolism. Our primary aim is to elucidate the impact of Crimean-Congo hemorrhagic fever (CCHF) on specific amino acid concentrations and identify potential metabolic markers associated with viral infection. One hundred ninety individuals participated in this study, comprising 115 CCHF patients, 30 CCHF negative patients, and 45 healthy controls. Liquid chromatography-tandem mass spectrometry techniques were employed to quantify amino acid concentrations. The amino acid metabolic profiles in CCHF patients exhibit substantial distinctions from those in the control group. Patients highlight distinct metabolic reprogramming, notably characterized by arginine, histidine, taurine, glutamic acid, and glutamine metabolism shifts. These changes have been associated with the underlying molecular mechanisms of the disease. Exploring novel therapeutic and diagnostic strategies addressing specific amino acids may offer potential means to mitigate the severity of the disease.en_US
dc.identifier.citationBüyüktuna, S. A., Yerlitaş, S. İ., Zararsız, G. E., Doğan, K., Kablan, D., Bağcı, G., Özer, S., Baysal, C., Çakır, Y., Cephe, A., Koçhan, N., Zararsız, G., Doğan, H. O. (2024). Exploring free amino acid profiles in CCHF patients: Implications for disease progression. Journal of Medical Virology, 96(5). 10.1002/jmv.29672en_US
dc.identifier.issn0146-6615
dc.identifier.issn1096-9071
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85193380919
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4701
dc.identifier.volume96en_US
dc.identifier.wosWOS:001232031300026
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBağcı, Gökhan
dc.language.isoen
dc.relation.ispartofJournal of Medical Virology
dc.relation.isversionof10.1002/jmv.29672en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCrimean‐Congo hemorrhagic feveren_US
dc.subjectLC‐MS/MSen_US
dc.subjectAmino aciden_US
dc.subjectSeverityen_US
dc.titleExploring free amino acid profiles in CCHF patients: Implications for disease progression
dc.typeArticle

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