The relationship between bifidobacteria and allergic asthma and/or allergic dermatitis: A prospective study of 0-3 years-old children in Turkey

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dc.contributor.authorAkay, Hatice Kubra
dc.contributor.authorTokman, Hrisi Bahar
dc.contributor.authorHatipoğlu, Nevin
dc.contributor.authorHatipoğlu, Huseyin
dc.contributor.authorSiraneci, Rengin
dc.contributor.authorDemirci, Mehmet
dc.contributor.authorKocazeybek, Bekir S.
dc.contributor.authorBorsa, Barış Ata
dc.date.accessioned2021-05-15T12:40:44Z
dc.date.available2021-05-15T12:40:44Z
dc.date.issued2014
dc.departmentTıp Fakültesien_US
dc.descriptionTokman, Hrisi Bahar/0000-0002-2205-5120; Sirekbasan, Serhat/0000-0001-7967-3539; Demirci, Mehmet/0000-0001-9670-2426; KARAKULLUKCU, ASIYE/0000-0002-7117-5102; Kocazeybek, Bekir S/0000-0003-1072-3846
dc.description.abstractBifidobacteria are beneficial bacteria for humans. These bacteria are particularly effective at protecting against infectious diseases and modulating the immune response. It was shown that in newborns, the fecal distribution of the colonizing Bifidobacterium species influences the prevalence of allergic diseases. This study aimed to compare the faecal Bifidobacterium species of allergic children to those of healthy children to detect species level differences in faecal distribution. Stool samples were obtained from 99 children between 0 and 3 years of age whose clinical symptoms and laboratory reports were compatible with atopic dermatitis and allergic asthma. Samples were also obtained from 102 healthy children who were similar to the case group with respect to age and sex. Bifidobacteria were isolated by culture and identified at the genus level by API 20 A. In addition, 7 unique species-specific primers were used for the molecular characterization of bifidobacteria. The McNemar test was used for statistical analyses, and p < 0.05 was accepted as significant. Bifidobacterium longum was detected in 11(11.1%) of the allergic children and in 31 (30.3%) of the healthy children. Statistical analysis revealed a significant difference in the prevalence of B. longum between these two groups (X-2: 11.2, p < 0.001). However, no significant differences in the prevalence of other Bifidobacterium species were found between faecal samples from healthy and allergic children. (p > 0.05). The significant difference in the isolation of B. longum from our study groups suggests that this species favors the host by preventing the development of asthma and allergic dermatitis. Based on these results, we propose that the production of probiotics in accordance with country-specific Bifidobacterium species densities would improve public health. Thus, country-specific prospective case control studies that collect broad data sets are needed. (C) 2014 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipIstanbul UniversityIstanbul University [13038]; Grants-in-Aid for Scientific ResearchMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [24580384] Funding Source: KAKENen_US
dc.description.sponsorshipThis study was supported by Istanbul University Research Found. Project and Grant No: 13038. We would like to thank for this support. We would like to thank also Mrs Beliz Bahar (Istanbul, TURKEY) and Ms. Tamar Leah Tokman (NJ,USA) in regards to taking the time to edit the grammatical omissions.en_US
dc.identifier.doi10.1016/j.anaerobe.2014.05.006
dc.identifier.endpage103en_US
dc.identifier.issn1075-9964
dc.identifier.issn1095-8274
dc.identifier.pmid24878320
dc.identifier.scopus2-s2.0-84904637352
dc.identifier.scopusqualityQ2
dc.identifier.startpage98en_US
dc.identifier.urihttps://doi.org/10.1016/j.anaerobe.2014.05.006
dc.identifier.urihttps://hdl.handle.net/20.500.12939/667
dc.identifier.volume28en_US
dc.identifier.wosWOS:000341348000017
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBorsa, Barış Ata
dc.language.isoen
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofAnaerobe
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBifidobacteriaen_US
dc.subjectAllergic Asthmaen_US
dc.subjectAllergic Dermatitisen_US
dc.subjectChildrenen_US
dc.subjectTurkeyen_US
dc.titleThe relationship between bifidobacteria and allergic asthma and/or allergic dermatitis: A prospective study of 0-3 years-old children in Turkey
dc.typeArticle

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